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pro vyhledávání: '"Ali H"'
Publikováno v:
Development
Although fate maps of early embryos exist for nearly all model organisms, a fate map of the gastrulating human embryo remains elusive. Here we use human gastruloids to piece together a rudimentary fate map for the human primitive streak (PS). This is
Publikováno v:
Development (Cambridge, England). 140(20)
One of the earliest steps in embryonic development is the specification of the germ layers, the subdivision of the blastula embryo into endoderm, mesoderm and ectoderm. Maternally expressed members of the Transforming Growth Factor β (TGFβ) family
The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm
Publikováno v:
Development (Cambridge, England). 135(3)
Mechanisms underlying regional specification of distinct organ precursors within the endoderm, including the liver and pancreas, are still poorly understood. This is particularly true for stages between endoderm formation and the initiation of organo
Autor:
Ariel J. Levine, Ali H. Brivanlou
Publikováno v:
Development (Cambridge, England). 133(2)
The TGFβ superfamily of ligands plays key functions in development and disease. In both human and mouse embryonic stem cells, a member of this family, GDF3, is specifically expressed in the pluripotent state. We show that GDF3 is an inhibitor of its
Publikováno v:
Development (Cambridge, England). 129(23)
The earliest decision in vertebrate neural development is the acquisition of a neural identity by embryonic ectodermal cells. The default model for neural induction postulates that neural fate specification in the vertebrate embryo occurs by inhibiti
Autor:
Richard M. Harland, Ali H. Brivanlou
Publikováno v:
Development (Cambridge, England). 106(3)
We have used a monoclonal antibody directed against the C-terminus of the Drosophila inverted homeodomain to detect a nuclear protein in brain cells of Xenopus laevis embryos. We refer to this antigen as the Xenopus EN protein. The EN protein is loca