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Autor:
Myriam Lemmens, Juliane Perner, Leon Potgeter, Michael Zogg, Sineha Thiruchelvam, Matthias Müller, Thierry Doll, Annick Werner, Yoann Gilbart, Philippe Couttet, Hans-Jörg Martus, Silvana Libertini
Publikováno v:
Cytotherapy. 25:59-67
Engineered tissues and cell therapies based on human induced pluripotent stem cells (iPSCs) represent a promising approach for novel medicines. However, iPSC-derived cells and tissues may contain residual undifferentiated iPSCs that could lead to ter
Autor:
Sara Azhari Mohamed, Aoife Duffy, Veronica McInerney, Janusz Krawczyk, Amjad Hayat, Sean Naughton, Andrew Finnerty, Miriam Holohan, Aaron Liew, Muhammad Tubassam, Stewart Redmond Walsh, Timothy O'Brien, Linda Howard
Publikováno v:
Cytotherapy. 24:1259-1267
Approximately 1 in 3 patients with critical limb ischemia (CLI) are not suitable for surgical or endovascular revascularization. Those "no-option" patients are at high risk of amputation and death. Autologous bone marrow mesenchymal stromal cells (MS
Autor:
Frederick W. Thielen, Renaud J.S.D. Heine, Sibren van den Berg, Renske M. T. ten Ham, Carin A. Uyl-de Groot
Publikováno v:
Cytotherapy, 24(12), 1245-1258. Elsevier Inc.
Background aims: Drug prices are regarded as one of the most influential factors in determining accessibility and affordability to novel therapies. Cell and gene therapies such as OTL-200 (brand name: Libmeldy) and AVXS-101 (brand name: Zolgensma) wi
Autor:
Katherine N. MacDonald, Michael G. Hall, Sabine Ivison, Sanjiv Gandhi, Ramon I. Klein Geltink, James M. Piret, Megan K. Levings
Publikováno v:
Cytotherapy. 24:1121-1135
Given the promising results from phase 1/2 clinical trials of therapy involving regulatory T cells (Tregs), it is critical to develop Treg manufacturing methods that use well-defined reagents.Seeking to maximize expansion of human thymic Tregs activa
Autor:
Ariana León-Sosa, Verónica Castañeda, Roberto Espinosa-Vallejo, Xavier Gómez, Ramiro F. Díaz, Francisco Cabrera, Andrés Caicedo
Publikováno v:
Cytotherapy. 24:1074-1086
Skin wound healing leads to the recovery of tissue structure and homeostasis after injury. Numerous factors can hamper wound healing and complete recovery of the harmed tissue, causing the formation of scars or chronic wounds. Therapeutic options to
Autor:
Tong, Lei, Zhuangzhuang, Xiao, XiaoShuang, Zhang, Shanglin, Cai, Wangyu, Bi, Yanjie, Yang, Donghui, Wang, Quanhai, Li, Hongwu, Du
Publikováno v:
Cytotherapy. 24:1105-1120
Gingival mesenchymal stem cells (GMSCs) demonstrate high proliferation, trilineage differentiation and immunomodulatory properties. Parkinson disease (PD) is the second most common type of neurodegenerative disease. This study aimed to explore the ef
Autor:
Shiwen Deng, Tong Lei, Hongyu Chen, Huiting Zheng, Zhuangzhuang Xiao, Shanglin Cai, Zhongci Hang, Weini Xiong, Yanqing Yu, Xiaoshuang Zhang, Yanjie Yang, Wangyu Bi, Hongwu Du
Publikováno v:
Cytotherapy. 24:1095-1104
Stem cells from human exfoliated deciduous teeth (SHED) play a significant role in tissue engineering and regenerative medicine. Angiogenesis is crucial in tissue regeneration and a primary target of regenerative medicine. As a first-line anti-diabet
Autor:
Mark Gurney, Eimear O'Reilly, Sarah Corcoran, Sarah Brophy, Janusz Krawczyk, Neil M. Otto, David L. Hermanson, Richard W. Childs, Eva Szegezdi, Michael E. O'Dwyer
Publikováno v:
Cytotherapy. 24:1087-1094
Natural killer (NK) cell genome editing promises to enhance the innate and alloreactive anti-tumor potential of NK cell adoptive transfer. DNA transposons are versatile non-viral gene vectors now being adapted to primary NK cells, representing import
Publikováno v:
Cytotherapy. 24:990-998
The network of public cord blood banks (CBBs) in Australia, known as AusCord, comprises CBBs located in Brisbane, Sydney and Melbourne. A novel comprehensive analysis has been performed to determine whether the cryopreserved, searchable cord blood un
Autor:
Qian Cheng, Jingwen Tan, Rui Liu, Liqing Kang, Yi Zhang, Erhua Wang, Ying Li, Jian Zhang, Han Xiao, Nan Xu, Minghao Li, Lei Yu, Xin Li
Publikováno v:
Cytotherapy. 24:1026-1034
The infusion of chimeric antigen receptor (CAR) T cells that target specific tumor-associated antigens is a promising strategy that has exhibited encouraging results in clinical trials. However, few studies have focused on the effectiveness and safet