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Publikováno v:
Cytokine. 113:238-247
Human macrophages produce vascular endothelial growth factor A (VEGFA) for angiogenesis in diabetic retinopathy (DR). The regulatory function of IL-27 on human macrophages is not well understood. In particular, the effect of IL-27 on VEGFA response i
Autor:
Mohammed M.H. Al-Gayyar, Nehal M. Elsherbiny, Mohamed A. Ebrahim, Amal M. El-Gayar, Nabila El Kramani
Publikováno v:
Cytokine. 111:523-529
In human hematologic malignancies, some of the TNF receptor family members are up-regulated and have the ability to evoke reactions favoring tumor progression. Moreover, cell migration molecules, Fascin-1 and Versican are involved in proliferation, m
Publikováno v:
Cytokine. 110:94-103
The pro-tumoral effects of CCL5 have been identified in numerous cancer types. We successfully cultivated 4 esophageal squamous cell carcinoma (ESCC) cell lines, including TWES-1, TWES-3 and a pair of cell lines derived from primary lesion (TWES-4PT)
Autor:
Andrzej Gamian, Iwona Bednarz-Misa, Bartosz Kapturkiewicz, Wojciech Witkiewicz, Sabina Górska, Małgorzata Krzystek-Korpacka, Paulina Lewandowska, Marek Zawadzki
Publikováno v:
Cytokine. 110:435-441
Colorectal cancers (CRCs) are treated as one entity but are in fact a heterogeneous group of diseases. If not addressed, subsite-associated variability may interfere with mechanism-targeted therapies and accuracy of potential CRC biomarkers. Little i
Autor:
Ewa Jabłońska, Wojciech Miltyk, Marcin Moniuszko, Marzena Garley, Kamil Grubczak, Jan Borys, Dorota Dziemiańczyk-Pakieła, Wioletta Ratajczak-Wrona
Publikováno v:
Cytokine. 137
Background The significant role played by neutrophils in cancer biology is indisputable; yet, their subpopulations may exhibit a contrasting role. The phenomenon of polarization of neutrophils and signaling modulators in the course of a neoplastic pr
Autor:
Imen Zamali, Monia Khanfir, Houman Mh, Mohamed-Ridha Barbouche, Skander Mrad, Soumaya Marzouki, Raja Rekik, Asma Beldi-Ferchiou, Melika Ben Ahmed, S. Hamzaoui, T. Larbi, Ons Kammoun
Publikováno v:
Cytokine
Cytokine, Elsevier, 2018, 108, pp.182-189. ⟨10.1016/j.cyto.2018.04.011⟩
Cytokine, Elsevier, 2018, 108, pp.182-189. ⟨10.1016/j.cyto.2018.04.011⟩
International audience; The mechanisms leading to the disruption of self-tolerance in systemic lupus erythematosus (SLE) remain elusive. Herein, we aimed to decipher the molecular basis of the impaired response of mononuclear cells to TGF-β1. The Sm
Publikováno v:
Cytokine. 107:35-42
Th17 cytokines have been identified in several types of human cancers. In this pilot study, the expression of Th17 cytokines profiling in enteroviruses 71 (EV71) associated colorectal cancer (CRC) were explored.66 patients with CRC were enrolled in t
Autor:
Ángel García-Cortés, David Rosell, Beatriz Mateos, Fernando Diez-Caballero, Alfonso Gurpide, Javier Ancizu-Marckert, B. Miñana, Mónica Macías, Ana Navarro, Oihane Bedialauneta, Daniel Ajona, Susana Chocarro, Alvaro Gonzalez, J.I. Pascual, Jose Luis Perez-Gracia, Marcos Torres, Maria Pilar Andueza, José Enrique Robles, Rodrigo Sánchez-Bayona, Estibaliz Alegre
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
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Background: Myeloid-derived suppressor cells (MDSCs) are relevant in prostate cancer microenvironment collaborating in tumor development. The main tumor marker used in this disease, prostate-specific antigen (PSA), does not provide information relate
Autor:
Satoshi Kuboki, Shintaro Maeda, Hiroyuki Nojima, Masaru Miyazaki, Hiroaki Shimizu, Hideyuki Yoshitomi, Masayuki Ohtsuka, Katsunori Furukawa
Publikováno v:
Cytokine. 95:12-21
Background Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. Chemokines play important roles in the progression of many malignancies; however, the role of chemokine receptor expression in clinical cases of PDAC is unclear. Moreover, lit
Autor:
Javier A. Menendez, Jordi Camps, Salvador Fernández-Arroyo, Vicente Martín-Paredero, J J Sirvent, Anna Hernández-Aguilera, Jorge Joven, Fedra Luciano-Mateo, Montserrat Fibla, Noemí Cabré
Publikováno v:
Cytokine. 126
Chemokines, particularly chemokine (C-C- motif) ligand 2 (CCL2), control leukocyte migration into the wall of the artery and regulate the traffic of inflammatory cells. CCL2 is bound to functional receptors (CCR2), but also to atypical chemokine rece