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Publikováno v:
Current Topics in Medicinal Chemistry. 17:1400-1407
Alzheimer's disease (AD) is an irreversible multifaceted neurodegenerative disorder that gradually degrades neuronal cells. Presently, it is the most common reason for the memory loss and dementia in older individuals. It is patho-physiologically des
Autor:
Alessandra Mascarello, Allisson Jhonatan Gomes Castro, Taisa Regina Stumpf, Marisa Jádna Silva Frederico, Camila Pires Mendes, Fátima Regina Mena Barreto Silva, Paulo César Leal, Ricardo José Nunes, Rosendo A. Yunes, Virginia Dermachi Kappel
Publikováno v:
Current Topics in Medicinal Chemistry. 12:2049-2058
In this study the in vivo and in vitro antidiabetic effects of four acylhydrazone derivatives were investigated in rats. The secretagogue action, oral glucose tolerance, insulinogenic index and mechanism of action of these acylhydrazones in relation
Publikováno v:
Current Topics in Medicinal Chemistry. 11:1047-1057
This paper presents an overview of the current knowledge about the role of adenosine in the sleep-wake regulation with a focus on adenosine in the central nervous system, regulation of adenosine levels, adenosine receptors, and manipulations of the a
Autor:
V. Craig Jordan, Eric A. Ariazi
Publikováno v:
Current Topics in Medicinal Chemistry. 6:203-215
While estrogen receptor (ER)-targeted therapeutics have clearly been a success in the treatment of breast cancer, the orphan estrogen-related receptors (ERRs) represent novel targets for future development. The ERRs, comprising ERRalpha, ERRbeta and
Publikováno v:
Current Topics in Medicinal Chemistry. 5:303-313
Arylacetamide analgesics that stimulate kappa opioid receptors in the central nervous system mediate dysphoria and psychosis as well as analgesia. However, the naturally occurring peptide agonist, dynorphin A, is analgesic in the absence of dysphoria