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Publikováno v:
Curr Pharm Des
Background: We recently reported a role for the circadian rhythm protein Period 2 (PER2) in midazolam induced cognitive dysfunction. Based on previous studies showing a critical role for the adenosine A2B receptor (ADORA2B) in PER2 regulation, we hyp
Publikováno v:
Current Pharmaceutical Design. 26:3001-3009
Although the morbidity of ulcers is statistically higher in males than females, the mechanism of this difference remains unknown. Recent studies show that duodenal HCO3 - response to mucosal acidification is higher in females than males, and this may
Publikováno v:
Current Pharmaceutical Design. 23:1869-1872
Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the function of multiple neurotransmitter pathways throughout the central nervous system. This includes nAChRs found on the proopiomelanocortin neurons in the hypothalamus. Activation of th
Autor:
Ana I. Giraldo, Eduardo Agüera, Macarena Aguilar-Luque, Begoña M. Escribano, Antonio H. Cruz, Fernando Sánchez-López, Rafael Lillo, Félix Gascón, Isaac Túnez, Carmen Bahamonde, Evelio Luque, Cristina Conde
Publikováno v:
Current Pharmaceutical Design. 22:4876-4880
Aims: The main aim of this study was to verify the effect of natalizumab on the levels of circulating catecholamines and indolamine and their possible relation with MS. Methods: For this purpose, 12 healthy individuals (control group) and 12 relapsin
Autor:
Arti Dhar, Kailash Prasad
Publikováno v:
Current Pharmaceutical Design. 22:141-144
Flaxseed contains 32% to 45% of its mass as oil of which 51% to 55% is α-linolenic acid. Flax lignan complex and secoisolariciresinol diglucoside (SDG) have been isolated from flaxseed. Flaxseed and its components have antioxidant, hypolipidemic and
Autor:
Christina Chrysohoou, Damien Gruson, Georgia Vogiatzi, Dimitris Tousoulis, Nikolaos Magkas, Ippokratis Bournelis, George Georgiopoulos, Sofia Bampali
Publikováno v:
Current Pharmaceutical Design. 23
Background: The failing heart is characterized by a depleted metabolic energy reserve and the up-regulation of several molecular mechanisms leading to cardiac hypertrophy, inflammation, fibrosis, angiogenesis, and apoptosis. Dietary or non-dietary su
Autor:
George M. Anderson, Michael Maes
Publikováno v:
Current Pharmaceutical Design. 20:3812-3847
This paper reviews recent work on the biological underpinnings of clinical depression emphasizing the crucial role of immunoinflammatory and oxidative and nitrosative stress (O&NS) pathways in driving changes in neuronal regulating tryptophan catabol
Publikováno v:
Current Pharmaceutical Design. 20:3579-3594
Many cardiovascular diseases and drug-induced complications are associated with - or even based on - an imbalance between the formation of reactive oxygen and nitrogen species (RONS) and antioxidant enzymes catalyzing the break-down of these harmful
Autor:
Elisa Mura, Alessia Salamone, Stefania Zappettini, Stefania Preda, Mario Marchi, Massimo Grilli, Anna Pittaluga, Marco Racchi, Cristina Lanni, Stefano Govoni, Guendalina Olivero
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
The review examines the multifaceted interactions between cholinergic transmission and beta-amyloid suggesting a continuum in the action of the peptide that at low concentrations (picomolar-low nanomolar) may directly stimulate nicotinic cholinergic
Publikováno v:
Current Pharmaceutical Design. 20:1156-1160
Aims: The aims of this study were to determine a mechanism and general timeline for statin related anti-inflammatory activity. Methods: Healthy male subjects received rosuvastatin (20 mg daily) for 3 weeks. Blood samples before and after treatment we