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Publikováno v:
Current Pharmaceutical Biotechnology. 23:1405-1414
Background: Our study seeks to obtain data to assess the impact of circPUM1 on pancreatic cancer (PC) and its mechanism. Methods: The expression of circPUM1 and miR-200c-3p in PC and normal tissues and PC cell lines was collected and detected, and su
Publikováno v:
Current Pharmaceutical Biotechnology. 20:1147-1154
Objective: MicroRNA (miR)-340-5p has been identified to play a key role in several cancers. However, the function of miR-340-5p in skin fibroblasts remains largely unknown. Methods: Gain of function experiments were performed by infecting normal skin
Autor:
Mona Saffarzadeh
Publikováno v:
Current Pharmaceutical Biotechnology. 19:1196-1202
Neutrophil extracellular traps (NET), extruded decondensated chromatin entangled with neutrophil proteases, have been first identified in neutrophils stimulated with bacteria or phorbol myristate acetate (PMA) via activation of NADPH oxidase and the
Autor:
Yoshiko Maida, Hiroshi Fujiwara, Mitsuhiro Nakamura, Akira Hattori, Kyosuke Kagami, Masanori Ono, Yukiyasu Sato, Yoshihiko Araki, Hisanori Matsumoto, Takiko Daikoku, Tomoko Fujiwara, Akihito Horie, Yasunari Mizumoto, Kazuhiko Imakawa
Publikováno v:
Current Pharmaceutical Biotechnology. 19:764-770
The invasion of an extravillous trophoblast (EVT) into maternal decidual tissues, especially towards maternal spiral arteries, is an essential process in the human placental formation and subsequent normal fetal development. However, the precise regu
Publikováno v:
Current Pharmaceutical Biotechnology. 19:644-663
Apoptosis, a form of programmed cell death, plays a very crucial role in various physiological processes for maintaining cell homeostasis. This process has several characteristic features like membrane blebbing, nuclear condensation, DNA fragmentatio
Autor:
Asuka Kumagai, Tomo Yonezawa, Riho Kurata, Yoshimasa Tanaka, Xiaofeng Cui, Kei-ichi Ozaki, Masamitsu Harada, Jun Nagai, Yasuhiro Yoshida
Publikováno v:
Current Pharmaceutical Biotechnology. 19:224-231
Background: Transcriptional regulation is a very important and pivotal function in myriad biological responses. Thus, methods to determine transcriptional activity are required in not only basic medical research but also in drug discovery. We establi
Publikováno v:
Current Pharmaceutical Biotechnology. 19:190-195
Background The gastrointestinal tract harbours a diverse bacterial community that contributes to health and disease. A number of studies have demonstrated that the gut microbiota plays a critical role in the metabolism of serotonin. Methods Microbial
Autor:
Vasileios G Igoumenou, Panayiotis D. Megaloikonomos, Adamantia Milonaki, M Kyriakidou, Evanthia A. Mitsiokapa, Georgios N. Panagopoulos, Jane Anastassopoulou, Leonidas Dimopoulos, Myrto Bami, Andreas F. Mavrogenis
Publikováno v:
Current Pharmaceutical Biotechnology. 19:19-29
Background Adipose tissue is one of the most attractive sources of stem cells because it can be easily harvested and yields a greater stromal cell density. The multilineage potential of adiposederived stem cells (ADSCs) demonstrates their significant
Publikováno v:
Scopus-Elsevier
Estrogen is one of the most important signaling molecules which targets a number of genes. Estrogen levels regulate cell proliferation and a plethora of metabolic processes, which may interfere with a range of medical conditions and drug metabolism.
Autor:
Yan Chen, Fei Zhao, Li J. Yang, Sha Yi, Ben P. Zhang, Ling L. Zeng, Chun Zhang, Zi C. Zhao, Jie Zhao, Lu Wen
Publikováno v:
Current Pharmaceutical Biotechnology. 17:147-160
As the principal active ingredient in the Chinese herb Tripterygium wilfordii Hook.F (TwHF), triptolide has been shown to have very strong antitumor properties. The trimethylation of lysine 4 on histone H3 (H3K4me3) has been proposed to promote gene