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Publikováno v:
Current Pharmaceutical Biotechnology. 2:241-256
The pharmaceutical industry has recently focused on intracellular signaling as a means to integrate the multiple facets of complex disease states, such as inflammation, because these pathways respond to numerous extracellular signals and coordinate a
Publikováno v:
Current Pharmaceutical Biotechnology. 2:77-111
Small heat shock proteins (sHSPs) belong to a family of 12- to 43-kDa proteins that are ubiquitous and are largely conserved in amino acid sequence among all organisms. The principal heat-shock proteins that have chaperone activity (that is, they pro
Autor:
Scott L. Diamond, Haiching Ma
Publikováno v:
Current Pharmaceutical Biotechnology. 2:1-17
Nonviral gene therapy has significant clinical potential, yet its therapeutic utility has been hindered by low transfection efficiency due to a combination of extracellular and intracellular barriers. Recent developments in formulation and delivery m
Publikováno v:
Current Pharmaceutical Biotechnology. 1:73-82
Anti-angiogenesis, i.e. inhibition of blood vessel growth, is being investigated as a way to prevent the growth of tumors and other angiogenesis-dependent diseases. Pharmacological inhibition interferes with the angiogenic cascade or the immature neo
Autor:
Ugo Ripamonti, J R Tasker
Publikováno v:
Current Pharmaceutical Biotechnology. 1:47-55
Tissue engineering is a rapidly developing field applying the disciplines of cell biology, developmental biology, molecular biology and biomimetic engineering to regenerate new tissues for replacement therapies in clinical contexts. To aid in the eli
Autor:
Antonio Diez, Ignacio Pérez-Roger, Enric Poch, Vicente Andrés, Marı́a José Cortés, Carmen Ivorra, Silvia M. Sanz-González
Publikováno v:
ResearcherID
Abnormal cellular proliferation is associated with the pathology of several diseases, including cancer, atherosclerosis and restenosis post-angioplasty. Therefore, anti-proliferative therapies may be a suitable approach to treat these disorders. Cand