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Autor:
Loren W. Runnels
Publikováno v:
Current Pharmaceutical Biotechnology. 12:42-53
Unique among ion channels, TRPM6 and TRPM7 garnered much interest upon their discovery as the first ion channels to possess their own kinase domain. Soon after their identification, the two proteins were quickly linked to the regulation of magnesium
Autor:
Christian Harteneck, Maik Gollasch
Publikováno v:
Current Pharmaceutical Biotechnology
Members of the classic type of transient receptor potential channels (TRPC) represent important molecules involved in hormonal signal transduction. TRPC3/6/7 channels are of particular interest as they are components of phospholipase C driven signall
Autor:
Peter Holzer
Publikováno v:
Current Pharmaceutical Biotechnology. 12:24-34
Several of the 28 mammalian transient receptor potential (TRP) channel subunits are expressed throughout the alimentary canal where they play important roles in taste, chemo- and mechanosensation, thermoregulation, pain and hyperalgesia, mucosal func
Autor:
Ming Zhao
Publikováno v:
Current Pharmaceutical Biotechnology. 11:693-700
The noninvasive detection of cell death has significant diagnostic values. Molecular events in apoptosis and necrosis are a source of valuable surrogate markers for the detection of cell death. Two classes of imaging agents are being developed for im
Autor:
Jason W. O'Neill, Jane Carter, Christopher Mehlin, Jue Zhang, John M. Delaney, Sophia Siu, Andrew Gates
Publikováno v:
Current Pharmaceutical Biotechnology. 11:241-245
The expression of proteins which do not express well on their own can be enhanced by linking them to human serum albumin (HSA) or antibody crystallizable fragment (Fc). The constructs shown here are designed to secrete the proteins after transient tr
Publikováno v:
Current Pharmaceutical Biotechnology. 11:188-197
Protein misfolding and aggregation in the brain have been implicated as a common molecular pathogenesis of various neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and the polyglutamine (po
Publikováno v:
Current Pharmaceutical Biotechnology. 11:175-179
Screening for protein interaction partners of ion channels helps to elucidate signaling cascades to cellular targets and processes for a better understanding of the origin of diseases. Most important are the cytosolic segments of membrane-bound volta
Autor:
Weidong Le, Guang Rui Luo
Publikováno v:
Current Pharmaceutical Biotechnology. 11:180-187
The homeostasis of the protein synthesis and degradation is crucial for cell survival. Most age-related neurodegenerative diseases are characterized by accumulation of aberrant protein aggregates in affected brain regions. The principal routes of int
Autor:
Gunnar P H Dietz
Publikováno v:
Current Pharmaceutical Biotechnology. 11:167-174
Cell-penetrating peptides (CPP), also called protein transduction domains (PTD), membrane-permeable peptides (MPP), or Trojan horse peptides, have been used in many different research areas. The delivery of heat shock proteins (Hsp) using CPP has bee
Publikováno v:
Current Pharmaceutical Biotechnology. 11:146-157
Small heat shock proteins (sHsps) are molecular chaperones ubiquitously distributed in numerous species, from bacteria to humans. A conserved C-terminal "alpha-crystallin" domain organized in a beta-sheet sandwich and oligomeric structure are common