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Publikováno v:
Current Opinion in Oncology. 16:19-24
Purpose of review Apoptosis, or programmed cell death, is a vital physiologic process to eliminate damaged or unwanted cells. Defects in apoptosis promote tumor formation and make cancer cells resistant to therapy. This review provides an overview of
Publikováno v:
Current Opinion in Oncology. 13:453-462
Apoptosis is a distinctive form of cell death that reflects cleavage of a subset of intracellular polypeptides by proteases known as caspases. Two major intracellular caspase cascades, one activated predominantly by death receptor ligands and the oth
Publikováno v:
Current Opinion in Oncology. 13:477-483
Histone deacetylase inhibitors are potent inducers of growth arrest, differentiation, or apoptotic cell death in a variety of transformed cells in culture and in tumor bearing animals. Histone deacetylases and the family of histone acetyl transferase
Autor:
Lea Harrington, Rena Oulton
Publikováno v:
Current Opinion in Oncology. 12:74-81
The presence of telomerase activity in most human tumors, but not in many normal somatic tissues, has raised considerable interest in telomerase as a possible anticancer therapy. Recent advances in the cloning and characterization of mammalian telome