Zobrazeno 1 - 10
of 251
pro vyhledávání: '"Lipids"'
Autor:
Mafalda Bourbon, Joana Rita Chora
Publikováno v:
Current Opinion in Lipidology. 32:96-102
Purpose of review To collect evidence on statin pharmacogenomics, and review what is known in this field for familial hypercholesterolemia (FH) patients. Recent findings There are well-known associations between specific single nucleotide polymorphis
Publikováno v:
Curr Opin Lipidol
Current opinion in lipidology, vol 32, iss 5
Current opinion in lipidology, vol 32, iss 5
PURPOSE OF REVIEW: This paper reviews the mechanisms of high density lipoprotein cholesterol immunomodulation in the context of the mechanisms of chronic inflammation and immunosuppression causing persistent inflammation, immunosuppression, and catab
Publikováno v:
Curr Opin Lipidol
Purpose of review Cardiovascular calcification, a common feature of atherosclerotic lesions, has long been known to associate with cardiovascular risk. The roles of lipoproteins in atherosclerosis are also established, and lipid-modifying therapies h
Autor:
Zohaib Iqbal, Handrean Soran, Maryam Ferdousi, Uazman Alam, Bilal Bashir, Rayaz A. Malik, Alise Kalteniece
Publikováno v:
Current Opinion in Lipidology. 32:249-257
Purpose of review Hyperlipidaemia is associated with the development of neuropathy. Indeed, a mechanistic link between altered lipid metabolism and peripheral nerve dysfunction has been demonstrated in a number of experimental and clinical studies. F
Publikováno v:
Current Opinion in Lipidology. 32:183-190
Purpose of review Sodium-glucose cotransporter 2 (SGLT2) inhibitors are widely used antihyperglycemic drugs that show remarkable cardiorenal protective effects in patients with or without type 2 diabetes. Furthermore, they are effective among patient
Publikováno v:
Current Opinion in Lipidology
Current opinion in lipidology, 32(2), 112-116. Lippincott Williams and Wilkins
Current opinion in lipidology, 32(2), 112-116. Lippincott Williams and Wilkins
Purpose of review The current review describes the development, clinical relevance and potential caveats of polygenic risk scores (PRS) for LDL cholesterol (LDL-C). Recent findings In recent years, a large number of common variants have been shown to
Autor:
Liam R. Brunham, Mark Trinder
Publikováno v:
Current Opinion in Lipidology. 32:103-111
Purpose of review Contemporary polygenic scores, which summarize the cumulative contribution of millions of common single-nucleotide variants to a phenotypic trait, can have effects comparable to monogenic mutations. This review focuses on the emergi
Publikováno v:
Current Opinion in Lipidology. 32:132-140
Purpose of review Amyloidosis is caused by the deposition of misfolded aggregated proteins called amyloid fibrils that in turn cause organ damage and dysfunction. In this review, we aim to summarize the genetic, clinical, and histological findings in
Publikováno v:
Current opinion in lipidology, 31(6), 347-355. Lippincott Williams and Wilkins
Purpose of review Studies reaffirm that familial hypercholesterolemia is more prevalent than initially considered, with a population frequency of approximately one in 300. The majority of patients remains unidentified. This warrants critical evaluati
Autor:
Nigel Capps, Handrean Soran, Ian McDowell, Andrew Neil, Jackie A. Cooper, Steve E. Humphries, Paul N. Durrington
Publikováno v:
Current Opinion in Lipidology. 31:167-175
Purpose of review The role of non-HDL-C in the identification and management of lipid disorders is not clearly defined, although UK guidelines recommend its wider use in assessing the need for lipid-lowering therapy and as a treatment target. Recent