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Publikováno v:
Curr Opin Cell Biol
The microtubule cytoskeleton is assembled from a finite pool of α,β-tubulin, the size of which is controlled by an autoregulation mechanism. Cells also tightly regulate the architecture and dynamic behavior of microtubule arrays. Here, we discuss p
Autor:
Amy S. Gladfelter, Benjamin L. Woods
Publikováno v:
Curr Opin Cell Biol
Septins are conserved guanine nucleotide-binding proteins that polymerize into filaments at the cell cortex or in association with other cytoskeletal proteins, such as actin or microtubules. As integral players in many morphogenic and signaling event
Publikováno v:
Curr Opin Cell Biol
Intermediate filaments (IFs) are key players in multiple cellular processes throughout human tissues. Their biochemical and structural properties are important for understanding filament assembly mechanisms, for interactions between IFs and binding p
Publikováno v:
Current Opinion in Cell Biology. 68:124-131
Microtubules are essential cytoskeletal elements assembled from αβ-tubulin dimers. In high eukaryotes, microtubule nucleation, the de novo assembly of a microtubule from its minus end, is initiated by the γ-tubulin ring complex (γ-TuRC). Despite
Publikováno v:
Curr Opin Cell Biol
Mitochondria form networks that continually remodel and adapt to carry out their cellular function. The mitochondrial network is remodeled through changes in mitochondrial morphology, number, and distribution within the cell. Mitochondrial dynamics d
Publikováno v:
Current Opinion in Cell Biology
Advanced in vitro models of human skeletal muscle tissue are increasingly needed to model complex developmental dynamics and disease mechanisms not recapitulated in animal models or in conventional monolayer cell cultures. There has been impressive p
Autor:
Himani Galagali, John Kim
Publikováno v:
Curr Opin Cell Biol
MicroRNAs (miRNAs) are major drivers of cell fate specification and differentiation. The post-transcriptional regulation of key molecular factors by microRNAs contributes to the progression of embryonic and postembryonic development in several organi
Autor:
Gabriella Rice, Panteleimon Rompolas
Publikováno v:
Curr Opin Cell Biol
The mammalian skin is equipped with a highly dynamic stratified epithelium. The maintenance and regeneration of this epithelium is supported by basally located keratinocytes which display stem cell properties, including lifelong proliferative potenti
Publikováno v:
Curr Opin Cell Biol
Asymmetric cell division produces two cells that are genetically identical but each have distinctly different cell fates. During this process, epigenetic mechanisms play an important role in allowing the two daughter cells to have unique gene express
Publikováno v:
Current Opinion in Cell Biology. 67:46-55
The proteostasis network adjusts protein composition and maintains protein integrity, which are essential processes for cell function and viability. Current efforts, given their intrinsic characteristics, regenerative potential and fundamental biolog