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Publikováno v:
Current Opinion in Cell Biology. 58:50-60
Central to eukaryotic cell function, transport into and out of the nucleus is largely mediated by members of the Importin (IMP) superfamily of transporters of α- and β-types. The first inhibitor of nuclear transport, leptomycin B (LMB), was shown t
Autor:
Tomoko Nishiyama
Publikováno v:
Current Opinion in Cell Biology. 58:8-14
Cohesin, one of structural maintenance of chromosomes (SMC) complexes, forms a ring-shaped protein complex, and mediates sister chromatid cohesion for accurate chromosome segregation and precise genome inheritance. The cohesin ring entraps one or two
Publikováno v:
Current Opinion in Cell Biology. 58:85-94
Ubiquitination is a versatile and tightly regulated post- translational protein modification with many distinct outcomes affecting protein stability, localization, interactions, and activity. Ubiquitin chain linkages anchored on substrates can be fur
Autor:
Rakefet Ben-Yishay, Yaron Shav-Tal
Publikováno v:
Current Opinion in Cell Biology. 58:69-75
The mRNA molecule roams through the nucleus on its way out to the cytoplasm. mRNA encounters and is bound by many protein factors, from the moment it begins to emerge from RNA polymerase II and during its travel in the nucleoplasm, where it will come
Autor:
Noriko Saitoh, Tatsuro Yamamoto
Publikováno v:
Current Opinion in Cell Biology. 58:26-33
Large-scale transcriptome analyses have identified a variety of non-coding RNAs (ncRNAs) that are not translated into proteins. Many of them are in the nucleus, where they associate with chromatin and regulate its structure and function. Interphase c
Autor:
Hironori Funabiki
Publikováno v:
Curr Opin Cell Biol
For equal chromosome segregation, a pair of kinetochores on each duplicated chromosome must attach to microtubules connecting to opposite poles. The protein kinase Aurora B plays a critical role in destabilizing microtubules attached in a wrong orien
Publikováno v:
Current Opinion in Cell Biology. 58:95-104
Chromatin in eukaryotic cells is a negatively charged polymer composed of DNA, histones, and various associated proteins. Over the past ten years, our view of chromatin has shifted from a static regular structure to a dynamic and highly variable conf
Autor:
Maya Capelson, Pau Pascual-Garcia
Publikováno v:
Curr Opin Cell Biol
Nuclear genome architecture relies on interactions between the genome and various nuclear scaffolds. One such a nuclear scaffold is the nuclear pore complex (NPC), which in addition to its nuclear transport function, can interact with underlying chro
Autor:
Zeinab Jahed, Mohammad R. K. Mofrad
Publikováno v:
Current Opinion in Cell Biology. 58:114-119
Mechanical signals affect many aspects of biological processes. Physical forces from the extracellular microenvironment are ultimately transmitted to the nucleus and elicit a response that result in the deformation and remodeling of the nucleus. Rece
Publikováno v:
Current Opinion in Cell Biology. 57:16-24
Advances in resolving crystal structures of GPCRs and their binding partners as well as improvements in live-cell microscopy and the fluorescent proteins pallet has greatly driven new ideas for designing optical sensors for the same. Sensors have bee