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Publikováno v:
Current Neurovascular Research. 17:241-248
Objective: It is reported that miR-26a-5p could regulate neuronal development, but its underlying mechanisms in Alzheimer’s disease (AD) progression is unclear. Methods: APP (swe)/PS1 (ΔE9) transgenic mice served as AD mice. Morris water maze test
Autor:
Kenneth Maiese
Publikováno v:
Current Neurovascular Research. 12:173-188
According to the World Health Organization, diabetes mellitus (DM) in the year 2030 will be ranked the seventh leading cause of death in the world. DM impacts all systems of the body with oxidant stress controlling cell fate through endoplasmic retic
Publikováno v:
Current Neurovascular Research. 10:93-102
The pigmented ciliary epithelium (PCE) of mammalian eye harbors resident population of stem cells that lie in apposition with endothelial cells which release vascular endothelial growth factor (VEGF) that may influence the fate and function of these
Publikováno v:
Current Neurovascular Research. 10:54-69
As a member of the secreted extracellular matrix associated proteins of the CCN family, Wnt1 inducible signaling pathway protein 1 (WISP1/CCN4) is garnering increased attention not only as a potent proliferative entity, but also as a robust cytoprote
Publikováno v:
Current Neurovascular Research. 10:4-10
Migration, proliferation and apoptosis of vascular smooth muscle cells (VSMCs) have recently been identified as important processes in a variety of human vascular diseases, including atherosclerosis, arterial injury, and restenosis after angioplasty.
Publikováno v:
Current Neurovascular Research. 6:267-278
Oxidative stress-induced cerebral endothelial cell dysfunction is associated with cerebral microvascular complication of primary diabetic encephaolopathy, a neurodegenerative disorder of long-standing diabetes, but the injury mechanisms are poorly un
Publikováno v:
Current Neurovascular Research. 6:20-31
Memory loss and cognitive failure are increasingly being identified as potential risks with the recognized increase in life expectancy of the general population. As a result, the development of novel therapeutic strategies for disorders such as Alzhe
Autor:
Kazuhiro Sakamaki
Publikováno v:
Current Neurovascular Research. 1:305-315
In multicellular organisms, apoptosis, also known as programmed cell death, is an important physiological response to eliminate unnecessary, excess, or harmful cells. Apoptosis occurs during embryonic development and is important in maintaining homeo
Autor:
Mervin C. Yoder, Rebecca J. Chan
Publikováno v:
Current Neurovascular Research. 1:197-206
Hematopoietic stem cells (HSCs) have long been defined as a cell with the capacity to repopulate the hematopoietic system of a lethally irradiated host. In clinical medicine, this property has been employed to reconstitute an individual's diseased he
Autor:
Wulf Paschen
Publikováno v:
Current Neurovascular Research. 1:173-181
The endoplasmic reticulum (ER) is a subcellular compartment playing a central role in folding and processing membrane and secretory proteins. The importance of these reactions for normal cellular function is indicated by the fact that blocking of the