Zobrazeno 1 - 7
of 7
pro vyhledávání: ''
Autor:
Jordan Ma
Publikováno v:
Current Medicinal Chemistry-Anti-Cancer Agents. 2:1-17
Microtubules, major structural components in cells, are the target of a large and diverse group of natural product anticancer drugs. Given the success of this class of drugs in cancer treatment, it can be argued that microtubules represent the single
Publikováno v:
Current Medicinal Chemistry-Anti-Cancer Agents. 5:183-199
DNA helicases have essential roles in nucleic acid metabolism by facilitating cellular processes including replication, recombination, DNA repair, and transcription. The vital roles of helicases in these pathways are reflected by their emerging impor
Autor:
Michelle Prudhomme
Publikováno v:
Current Medicinal Chemistry-Anti-Cancer Agents. 4:435-438
During the cell cycle that leads to mitosis, checkpoints are activated in response to DNA damage. The checkpoints control the ability of cells to arrest the cell cycle allowing time to repair the DNA. In more than 50% of cancer cells, the G1 checkpoi
Publikováno v:
Current Medicinal Chemistry-Anti-Cancer Agents. 4:379-387
Prostaglandins (PGs) are involved in mediating or regulating many physiological as well as pathological processes. Important roles of PGs in the pathophysiology of carcinogenesis offer potentials of targeting PG synthesis and PG receptors in developi
Autor:
Shinji Osada, Shigetoyo Saji
Publikováno v:
Current Medicinal Chemistry-Anti-Cancer Agents. 3:119-131
Although it has been widely known that extracellular signal-regulated kinase (ERK) pathway stimulates cell growth and have a protective effect from cell death, recent findings propose pro-apoptotic action of ERK phosphorylation. Since it was found th
Autor:
M Pruschy, Angela Tenzer
Publikováno v:
Current Medicinal Chemistry-Anti-Cancer Agents. 3:35-46
Cell cycle checkpoints are activated in response to DNA-damage to ensure that accurate copies of the cellular genome are passed on to the next generation and to avoid replication and segregation of damaged DNA. These cellular control systems can be o
Publikováno v:
Current Medicinal Chemistry-Anti-Cancer Agents. 2:727-742
DNA double strand breaks are the pivotal cellular damage induced by ionizing radiation. A plethora of molecular and cellular processes are activated as part of the cellular stress response that result in cell cycle arrest and induction of the DNA-rep