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pro vyhledávání: '"Rafael Coveñas"'
Autor:
Manuel Lisardo Sánchez, Rafael Coveñas
Publikováno v:
Current Medicinal Chemistry. 29:3231-3260
Background: The scientific interest regarding the involvement of peptides in cancer has increased in the last few years. In tumor cells, the overexpression of peptides and their receptors is known, and new therapeutic targets for the treatment of can
Publikováno v:
Current medicinal chemistry.
Background: Although chemotherapy is predominantly used for cancer treatment, it can be ineffective and can induce serious side effects and lead to chemoresistance. It is essential to discover novel drugs that can enhance the antitumor activity and a
Autor:
F D Rodriguez, Rafael Coveñas
Publikováno v:
Current Medicinal Chemistry. 24
Background The term Alcohol Use Disorder (AUD) incorporates different states of disease related to the recurrent use of alcohol and linked to the relevant impairment, disability and failure to perform major responsibilities in different realms. Many
Autor:
Miguel Muñoz, Rafael Coveñas
Publikováno v:
Current Medicinal Chemistry. 18:1820-1831
The neuropeptide substance P (SP) shows a widespread distribution in both the central and peripheral nervous systems and it is known that after binding to the neurokinin-1 (NK-1) receptors, SP regulates many biological functions in the central nervou
Publikováno v:
Current Medicinal Chemistry. 16:3203-3214
GEMSP is a mixture of functional polypeptides: fatty acids linked to poly-L-Lysine (PL), antioxidants linked to PL, free radical scavengers linked to PL, and amino acids linked to PL (patent numbers 6114388 (USA) and 792167 (EU)). In this review, we
Autor:
Rafael Coveñas, Felix-Martin Werner
Publikováno v:
Current medicinal chemistry. 20(38)
We summarize the alterations of classical neurotransmitters and neuropeptides and the corresponding subreceptors involved in major depression. Neuronal circuits in the brainstem, hippocampus and hypothalamus are developed, since they can be used to d
Autor:
Rafael Coveñas, Felix-Martin Werner
Publikováno v:
Current medicinal chemistry. 18(32)
We describe the alterations of classical neurotransmitters and neuropeptides in generalized epilepsy. A neuronal network in this disease is developed. Gamma aminobutyric acid (GABA) hypoactivity induces dopamine hyperactivity because dopaminergic neu
Autor:
F D Rodriguez, Rafael Coveñas
Publikováno v:
Current medicinal chemistry. 18(28)
Alcoholism is a multifarious and ongoing disease tightly related to the amount of alcohol ingested, the drinking pattern, the history of alcohol drinking and the individual features, such as some genetic traits. Worldwide alcohol is the necessary cau
Publikováno v:
Current medicinal chemistry. 17(6)
The past two decades have witnessed an exponential increase in research into cancer. This effort, however, has not been translated into better perspectives as regards the problem, although several fields of research have certainly been promising (the