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Publikováno v:
Current Medical Research and Opinion. 27:1781-1792
To compare the efficacy and safety of different dosages of alogliptin with that of placebo and voglibose in drug-naïve Japanese patients with type 2 diabetes inadequately controlled by diet and exercise.In the double-blind, placebo-controlled phase
Autor:
Daniel D. Mikol, Jason D Gardner, Bernard M. J. Uitdehaag, Frederik Barkhof, Patricia K. Coyle, Douglas Jeffery
Publikováno v:
Uitdehaag, B M J, Barkhof, F, Coyle, P K, Gardner, J D, Jeffery, D R & Mikol, D D 2011, ' The changing face of multiple sclerosis clinical trial populations ', Current Medical Research and Opinion, vol. 27, no. 8, pp. 1529-1537 . https://doi.org/10.1185/03007995.2011.591370
Current Medical Research and Opinion, 27(8), 1529-1537. Taylor and Francis Ltd.
Current Medical Research and Opinion, 27(8), 1529-1537. Taylor and Francis Ltd.
Since the commercial introduction of disease-modifying drugs (DMDs) for the treatment of multiple sclerosis (MS), there have been numerous randomized placebo-controlled and head-to-head clinical trials assessing the efficacy and safety of these agent
Publikováno v:
Current Medical Research and Opinion. 25:1563-1571
The purpose of this study was to determine if empirically observed differences in patient perception of, and satisfaction with, onset of effect between an active maintenance treatment and placebo are clinically meaningful to practicing clinicians. A
Publikováno v:
Current Medical Research and Opinion. 24:3029-3035
Chondroitin sulfate has been shown to relieve pain and improve functional limitation in patients with osteoarthritis (OA) of the knee in numerous clinical trials and meta-analyses. Its role as a potential structure-modifying drug for knee OA, however
Autor:
Anna Maria Riccio, Laura Guerra, Federica Fumagalli, Ilaria Baiardini, Antonio Scordamaglia, Giorgio Walter Canonica, Anthi Rogkakou, Global Allergy, Enrico Compalati, Pierangela Massacane, Giovanni Passalacqua, Cinzia Gamalero
Publikováno v:
Current Medical Research and Opinion. 24:2829-2839
Allergic rhinitis is a high-prevalence disease that affects quality of life (QOL), sleep quality and productivity of patients. According to the ARIA initiative, it is classified as intermittent and persistent, the latter being the most troublesome.Th
Autor:
Astrid Gendolla
Publikováno v:
Current Medical Research and Opinion. 21:S3-S7
Migraine is characterised by recurrent episodes of head pain, often accompanied by other symptoms, such as nausea and vomiting. In addition to migraine impairing a patient's ability to function normally during an attack, fear of the next attack can d
Publikováno v:
Current medical research and opinion
Objective: Prospective evaluation of the long-term efficacy and safety of the 5% lidocaine medicated plaster in patients with post-herpetic neuralgia (PHN). Research design and methods: Patients with persisting pain for >= 3 months after acute herpes
Publikováno v:
Current medical research and opinion. 28(1)
Limited data define what constitutes a clinically significant change on the Timed 25-Foot Walk (T25FW) in multiple sclerosis (MS); however, most studies suggest a value of ≥20%. Analyses were undertaken to estimate the minimally important clinical
Publikováno v:
Current medical research and opinion. 27(12)
To determine the efficacy, tolerability, and safety of duloxetine when added to oral nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with osteoarthritis (OA) of the knee with pain of moderate or greater severity.This was a 10-week randomize
Autor:
Lauren B. Marangell, Murali Gopal, Paula J. Gaynor, Michael J. Robinson, Wei Zheng, James M. Martinez
Publikováno v:
Current medical research and opinion. 27(10)
Painful physical symptoms are common in patients with major depressive disorder (MDD) and may predict poorer treatment outcomes. Duloxetine has demonstrated efficacy in treating both MDD and certain other painful conditions. This randomized, double-b