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Publikováno v:
Current Medical Research and Opinion. 27:1781-1792
To compare the efficacy and safety of different dosages of alogliptin with that of placebo and voglibose in drug-naïve Japanese patients with type 2 diabetes inadequately controlled by diet and exercise.In the double-blind, placebo-controlled phase
Autor:
Hong-Jun Cho, Cristina Russ, Theodore C. Lee, Wendy Ma, Simon J. C. Davies, Chen Wang, Karl Fagerström, Shih-Tzu Tsai, Masakazu Nakamura
Publikováno v:
Current Medical Research and Opinion. 26:2165-2173
A pooled analysis to evaluate the efficacy and safety of varenicline versus placebo for smoking cessation in Asian populations. A secondary objective was to compare the data to pooled trials among predominantly Western populations.Smokers (n = 893) i
Publikováno v:
Current Medical Research and Opinion. 25:1563-1571
The purpose of this study was to determine if empirically observed differences in patient perception of, and satisfaction with, onset of effect between an active maintenance treatment and placebo are clinically meaningful to practicing clinicians. A
Publikováno v:
Current Medical Research and Opinion. 24:3029-3035
Chondroitin sulfate has been shown to relieve pain and improve functional limitation in patients with osteoarthritis (OA) of the knee in numerous clinical trials and meta-analyses. Its role as a potential structure-modifying drug for knee OA, however
Autor:
Siddharth Kumar Das, Anil Pareek, Rajinder Singh Chauhan, Ragini Srivastava, Girdhar G. Agarwal, Ajay Wanchu, D. S. Mathur
Publikováno v:
Current Medical Research and Opinion. 23:2227-2234
Hydroxychloroquine (HCQ) has been used for a long time worldwide as a therapy for rheumatoid arthritis (RA). This trial was designed to determine whether HCQ was efficacious and safe in Indian patients with RA.The trial was a multicentre, placebo con
Publikováno v:
Current medical research and opinion. 28(2)
Placebo effects are well-known phenomena in medicine and biology. In fact, placebos are used as control conditions in randomized cross-over clinical trials to validate new treatments. Only recently, however, has it become apparent that the conditioni
Publikováno v:
Current medical research and opinion. 28(1)
Limited data define what constitutes a clinically significant change on the Timed 25-Foot Walk (T25FW) in multiple sclerosis (MS); however, most studies suggest a value of ≥20%. Analyses were undertaken to estimate the minimally important clinical
Publikováno v:
Current medical research and opinion. 25(10)
Pulmonary arterial hypertension (PAH) is a rare, progressive lung disorder that impairs performance of daily activities and quality of life (QoL), leading to right heart failure and death. Treatment options include prostanoids, endothelin antagonists
Publikováno v:
Current medical research and opinion. 25(5)
Baseline clinical and health-related quality of life (HRQoL) data from a phase 2, multi-site, international, randomized, controlled trial were analyzed to: (1) characterize the health status of patients with relapsing-remitting multiple sclerosis (RR
Publikováno v:
Current medical research and opinion. 25(2)
Interpretation of data from health-related quality of life (HRQoL) questionnaires can be enhanced with the availability of minimally important difference (MID) estimates. This information will aid clinicians in interpreting HRQoL differences within p