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Autor:
Liu Handong, Hu Keqi
Publikováno v:
Current Cancer Drug Targets. 21:526-535
Background: The role and mechanism of long non-coding RNA cytoskeleton regulator (CYTOR) in Invasive Pituitary Adenomas (IPA) have not been elucidated previously. Objective: This study aimed to investigate the interaction between CYTOR and miR-206 an
Publikováno v:
Current Cancer Drug Targets. 21:91-106
Matrix metalloproteinases (MMPs) are a group of zinc-dependent metalloendopeptidases that are responsible for the degradation, repair, and remodeling of extracellular matrix components. MMPs play an important role in maintaining a normal physiologica
Publikováno v:
Current Cancer Drug Targets. 20:821-830
Background: Current gene therapy vectors such as viral, non-viral, and bacterial vectors, which are used for cancer treatment, but there are certain safety concerns and stability issues of these conventional vectors. Exosomes are the vesicles of size
Publikováno v:
Current Cancer Drug Targets. 20:741-756
Several subtypes of T cells are located in a tumor environment, each of which supplies their energy using different metabolic mechanisms. Since the cancer cells require high levels of glucose, the conditions of food poverty in the tumor environment c
Emerging Multi-cancer Regulatory Role of ESRP1: Orchestration of Alternative Splicing to Control EMT
Publikováno v:
Current Cancer Drug Targets. 20:654-665
RNA binding proteins (RBPs) associate with nascent and mature RNAs to perform biological functions such as alternative splicing and RNA stability. Having unique RNA recognition binding motifs, RBPs form complexes with RNA in a sequence- and structure
Autor:
John C. Gore, Jingping Xie
Publikováno v:
Current Cancer Drug Targets. 20:364-371
Aims: Characterization of a small anticancer compound. Background: The development of small molecules as new anti-cancer therapeutics is necessary to improve anti-tumor efficacy and reduce toxicities, especially for the treatment of brain tumors, whe
Autor:
Jakaria Shawon, Mohammad A. Halim, Kazi Saif, Mahdi Safaei Khorram, Rudolf Kiefer, Mousumi Tania, Md. Asaduzzaman Khan
Publikováno v:
Current Cancer Drug Targets. 19:152-159
Background: Cordycepin is a small molecule from medicinal mushroom Cordyceps, which has been reported for anticancer properties. Objective: In this study, we have focused on the investigation of cordycepin effect on cervical cancer cells with further
Autor:
Mozafar Khazaei, Soraya Sajadimajd
Publikováno v:
Current Cancer Drug Targets. 18:538-557
Oxidative stress due to imbalance between ROS production and detoxification plays a pivotal role in determining cell fate. In response to the excessive ROS, apoptotic signaling pathway is activated to promote normal cell death. However, through dereg
Publikováno v:
Current Cancer Drug Targets. 18:514-521
Currently Cancer is the leading cause of death worldwide. Malignancy or cancer is a class of diseases characterized by uncontrolled cell growth that eventually invade other tissues and develop secondary malignant growth at other sites by metastasis.
Autor:
Jian-Xin Pu, Clara Bik-San Lau, Grace Gar-Lee Yue, Xunian Zhou, Stephen Kwok-Wing Tsui, Kwok-Pui Fung
Publikováno v:
Current Cancer Drug Targets. 18:239-255
Autophagy is an intracellular lysosomal/vacuolar degradation system, in which the inner cytoplasmic cell membrane is degraded by the lysosomal hydrolases, followed by the resulting products released back into the cytosol. It is involved in many physi