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pro vyhledávání: '"Geert J. P. L. Kops"'
Autor:
Palak Sekhri, Geert J. P. L. Kops, Anand Banerjee, John J. Tyson, Carlos Sacristan, Ian P. Whitney, Ajit P. Joglekar, Adrienne N. Fontan, David M Kern, Iain M. Cheeseman, Chu Chen
Publikováno v:
Current Biology, 29(1), 104-119.e10. Cell Press
Switch-like activation of the Spindle Assembly Checkpoint (SAC) is critical for accurate chromosomes segregation and for cell division in a timely manner. To determine the mechanisms that achieve this, we engineered an ectopic, kinetochore-independen
Autor:
Geert J. P. L. Kops
Publikováno v:
Current Biology
Summary Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1]. In response to unattached kinetochores, the mito