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Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 467-476 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Effective treatment or vaccine is not yet available for combating SARS coronavirus 2 (SARS-CoV-2) that caused the COVID-19 pandemic. Recent studies showed that two drugs, Camostat and Nafamostat, might be repurposed to treat C
Effective treatment or vaccine is not yet available for combating SARS coronavirus 2 (SARS-CoV-2) that caused the COVID-19 pandemic. Recent studies showed that two drugs, Camostat and Nafamostat, might be repurposed to treat C
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 577-585 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Enzyme thermostabilization is considered a critical and often obligatory step in biosynthesis, because thermostability is a significant property of enzymes that can be used to evaluate their feasibility for industrial applicat
Enzyme thermostabilization is considered a critical and often obligatory step in biosynthesis, because thermostability is a significant property of enzymes that can be used to evaluate their feasibility for industrial applicat
Autor:
Jack E. Richman, Lawrence P. Wackett, Kelly G. Aukema, Megan D. Smith, Lambros J. Tassoulas, Troy A. Biernath
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3087-3096 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract The thiolase enzyme OleA initiates the biosynthesis of β-lactone natural products and membrane hydrocarbons via acyl-Coenzyme A (CoA) substrates, but this study showed that p-nitrophenyl alkanoates can substitute, yielding new ins
Autor:
William R. Jacobs, Maria A. Pasillas, Ailidh Burgess, Tom L. Blundell, Sangeeta Tiwari, Anthony G. Coyne, James Cory-Wright, Vitor Mendes, Clio Meghir, Víctor Sebastián-Pérez, Sherine E. Thomas, Shaymaa A. Zaidan, Emma Cattermole, Pooja Gupta, Chris Abell
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3491-3506 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Computational and Structural Biotechnology Journal
'Computational and Structural Biotechnology Journal ', vol: 19, pages: 3491-3506 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Computational and Structural Biotechnology Journal
'Computational and Structural Biotechnology Journal ', vol: 19, pages: 3491-3506 (2021)
16 p.-8 fig.-4 tab.
The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of Mycobacterium tuberculosis are rapidly sterilised in
The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of Mycobacterium tuberculosis are rapidly sterilised in
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1383-1390 (2020)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Highlights • The phylogenetic distribution of GT1 family enzymes showed domain-dependent pattern. • The domain-dependent characterized GTs showed distinct substrates spectrum. • Two regions that discriminate the GT1 enzy
Highlights • The phylogenetic distribution of GT1 family enzymes showed domain-dependent pattern. • The domain-dependent characterized GTs showed distinct substrates spectrum. • Two regions that discriminate the GT1 enzy
Autor:
Sascha Schäuble, Sara Calcinaro, Anna Kleyman, Michael Bauer, Waqas Khaliq, Peter Großmann, David Brealey, Mervyn Singer, Michael Kiehntopf, Markus H. Gräler, Sophie Neugebauer, Gianni Panagiotou, Roberta Domizi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 3678-3691 (2020)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Sepsis remains a major cause of death despite advances in medical care. Metabolic deregulation is an important component of the survival process. Metabolomic analysis allows profiling of critical metabolic functions with the p
Sepsis remains a major cause of death despite advances in medical care. Metabolic deregulation is an important component of the survival process. Metabolomic analysis allows profiling of critical metabolic functions with the p
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 933-941 (2020)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Pharmaceutical heparin’s activity arises from a key high affinity and high selectivity antithrombin binding motif, which forms the basis for its use as an anticoagulant. The current problems with the supply of pig heparin ra
Pharmaceutical heparin’s activity arises from a key high affinity and high selectivity antithrombin binding motif, which forms the basis for its use as an anticoagulant. The current problems with the supply of pig heparin ra
Autor:
Shankar Prasad Kanaujia, Prerana Gogoi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 333-344 (2019)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Pentose bisphosphate pathway, exclusively found in archaea, is similar to the pentose phosphate pathway present in bacteria and eukarya. In pentose bisphosphate pathway, the conversion of ribose moieties of nucleosides into 3-phosphoglycerate (3-PGA)
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 638-644 (2019)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
RNA polymerase (RNAP) from bacteriophage T7 is a representative single-subunit viral RNAP that can transcribe with high promoter activities without assistances from transcription factors. We accordingly studied this small transcription machine comput
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 3, Iss 4 (2012)
Computational and Structural Biotechnology Journal, Vol 3, Iss 4, p e201210005 (2012)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 3, Iss 4, p e201210005 (2012)
Computational and Structural Biotechnology Journal
Microbial biocatalysts such as Escherichia coli and Saccharomyces cerevisiae have been extensively subjected to Metabolic Engineering for the fermentative production of biorenewable fuels and chemicals. This often entails the introduction of new enzy