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Autor:
Stephen I. Rennard, Nancy A. Rigotti, David Gonzales, Raafat E F Fahim, Matthew W Kalnik, Douglas E. Jorenby, Elbert D. Glover, Dorothy K. Hatsukami, Donald P. Tashkin, Cheryl Oncken, Minoo Niknian, Victor I. Reus, Paul D. Kessler, Roxanne C. Akhavain
Publikováno v:
Clinical pharmacology and therapeutics
Clinical pharmacology and therapeutics, vol 89, iss 3
Clinical pharmacology and therapeutics, vol 89, iss 3
NicVAX, a nicotine vaccine (3'AmNic-rEPA), has been clinically evaluated to determine whether higher antibody (Ab) concentrations are associated with higher smoking abstinence rates and whether dosages and frequency of administration are associated w
Autor:
Jörn Lötsch, John J. Greer, Helmut Schmidt, Bruno G. Oertel, M A Varney, S Johnson, Gerd Geisslinger, Lisa Felden, Martin S. Angst, P V Tran, M H Bradshaw
Publikováno v:
Clinical pharmacology and therapeutics. 87(2)
Ventilatory depression is a significant risk associated with the use of opioids. We assessed whether opioid-induced ventilatory depression can be selectively antagonized by an ampakine without reduction of analgesia. In 16 healthy men, after a single
Publikováno v:
Clinical Pharmacology and Therapeutics. 49:350-354
The central nervous system effect of acetaminophen (paracetamol) and acetylsalicylic acid was investigated in healthy volunteers according to a crossover, double-blind, and placebo-controlled design. Ten subjects received, by intravenous route, a pla
Publikováno v:
Clinical pharmacology and therapeutics. 83(4)
Varenicline is an alpha(4)beta(2) nicotinic acetylcholine receptor partial agonist developed as an aid for smoking cessation. This study evaluated varenicline's potential for abuse by smokers (n = 23) and nonsmokers (n = 22). The study used a randomi
Publikováno v:
Clinical Pharmacology and Therapeutics. 48:375-380
Calcium antagonists have been shown to depress hepatic enzymes and accelerate hepatic blood flow. This study was designed to compare the effects of two calcium antagonists, isradipine and diltiazem, on antipyrine and indocyanine green (ICG) clearance
Autor:
Carl V. Manion, Allen B. Edmundson
Publikováno v:
Clinical pharmacology and therapeutics. 63(5)
Background The binding of sweet-tasting compounds in a human (Mcg) Bence-Jones dimer has been characterized by x-ray crystallography. Aspartame binding in this immunoglobulin fragment is remarkable. Unexpected pain relief noted by A.B.E., a crystallo
Autor:
Theodore F. Reiss, Inge De Lepeleire, Ji Zhang, Albert Botto, F Rochette, Sudeep Kundu, Marc Decramer
Publikováno v:
Clinical pharmacology and therapeutics. 61(1)
Montelukast, a new specific oral cysteinyl LT1-receptor antagonist was evaluated for its activity in attenuating inhaled leukotriene D4 (LTD4) bronchoconstriction in patients with asthma. In two double-blind, placebo-controlled, randomized crossover
Autor:
Yves Lecrubier, Sophie Saïd, Robert Olivares, Ivan Berlin, Véronique Millet, Odile Spreux-Varoquaux, Jean-Marie Launay, Alain J. Puech
Publikováno v:
Clinical pharmacology and therapeutics. 58(4)
Objective To assess the effectiveness of moclobemide on smoking cessation and abstinence in heavy, dependent smokers. There is a strong association between smoking and depression, especially in dependent smokers. It was hypothesized that smoking is a
Autor:
William T. Beaver, Joseph R. Migliardi, Michael Friedman, Dennis B. Gillings, Joseph J Armellino
Publikováno v:
Clinical pharmacology and therapeutics. 56(5)
Six randomized, double-blind, two-period crossover studies, conducted under similar protocols, compared the efficacy of two analgesic combinations containing caffeine with an acetaminophen 1000 mg control and with a placebo in outpatients with episod
Publikováno v:
Clinical pharmacology and therapeutics. 55(5)
The nicotine metabolite cotinine was administered to abstinent cigarette smokers to determine whether it has pharmacologic activity as assessed by various physiologic and subjective measurements. By means of a randomized, double-blind, placebo-contro