Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Eric L. Nuermberger"'
Autor:
Devyani Deshpande, Shashikant Srivastava, Jotam G. Pasipanodya, Eric L. Nuermberger, Soumya Swaminathan, Tawanda Gumbo
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background. The regimen of linezolid and moxifloxacin was found to be efficacious in the hollow fiber system model of pediatric intracellular tuberculosis. However, its kill rate was slower than the standard 3-drug regimen of isoniazid, rifampin, and
Autor:
Eric L. Nuermberger, Shashikant Srivastava, Soumya Swaminathan, Tawanda Gumbo, Jotam G. Pasipanodya, Devyani Deshpande
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background. When treated with the same antibiotic dose, children achieve different 0- to 24-hour area under the concentration-time curves (AUC0–24) because of maturation and between-child physiological variability on drug clearance. Children are al
Autor:
Devyani Deshpande, Tawanda Gumbo, Eric L. Nuermberger, Soumya Swaminathan, Shashikant Srivastava, Jotam G. Pasipanodya
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background. No treatment regimens have been specifically designed for children, in whom tuberculosis is predominantly intracellular. Given their activity as monotherapy and their ability to penetrate many diseased anatomic sites that characterize dis
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 61
Background The in vitro hollow fiber system model of tuberculosis (HFS-TB), in tandem with Monte Carlo experiments, was introduced more than a decade ago. Since then, it has been used to perform a large number of tuberculosis pharmacokinetics/pharmac
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 61
BACKGROUND The hollow fiber system model of tuberculosis (HFS-TB) is designed to perform pharmacokinetics/pharmacodynamics (PK/PD) experiments, and hence the design of optimal doses and dose schedules for the treatment of tuberculosis. To determine i
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 62(4)
The disappointing recent failure of fluoroquinolone-containing regimens to shorten the duration of tuberculosis treatment in costly phase 3 trials has raised serious questions about the reliability of preclinical tuberculosis models, especially mice,
Autor:
William R. Bishai, Eric L. Nuermberger
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 38
The recent emergence of strains of drug-resistant Streptococcus pneumoniae (DRSP) is a serious clinical and public health problem. Several interventions have been proposed to limit the further emergence and spread of DRSP, including campaigns for app