Zobrazeno 1 - 9
of 9
pro vyhledávání: '"William D. Tap"'
Autor:
Laura M. Madanat-Harjuoja, Kelly Klega, Yao Lu, David S. Shulman, Aaron R. Thorner, Anwesha Nag, William D. Tap, Denise K. Reinke, Lisa Diller, Karla V. Ballman, Suzanne George, Brian D. Crompton
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 28(12)
Purpose: We sought to determine whether the detection of circulating tumor DNA (ctDNA) in samples of patients undergoing chemotherapy for advanced leiomyosarcoma (LMS) is associated with objective response or survival. Experimental Design: Using ultr
Autor:
Nicholas D. Klemen, Sinchun Hwang, Martina Bradic, Evan Rosenbaum, Mark A. Dickson, Mrinal M. Gounder, Ciara M. Kelly, Mary L. Keohan, Sujana Movva, Katherine A. Thornton, Ping Chi, Benjamin A. Nacev, Jason E. Chan, Edmund K. Bartlett, Allison L. Richards, Samuel Singer, Mark T.A. Donoghue, William D. Tap, Sandra P. D'Angelo
Publikováno v:
Clin Cancer Res
Purpose: Programmed cell death protein 1 (PD-1) blockade can mediate objective responses in advanced sarcomas, but their durability has not been established and it is unclear if hyperprogressive disease (HPD) occurs in sarcomas treated with PD-1 inhi
Autor:
Paul S. Lin, Charles Peterfy, Andrew J. Wagner, John H. Healey, Mike Sterba, Gregory M. Cote, Paul Severson, Heather L. Gelhorn, Eric J. Sherman, Chao Zhang, Henry H. Hsu, Geoffrey I. Shapiro, Arun S. Singh, Sandra Tong-Starksen, Stephen P. Anthony, Bartosz Chmielowski, Fadi Braiteh, Allen Lee Cohn, Igor Puzanov, William D. Tap, Brian L. West, Vicki L. Keedy, Xin Ye, Zev A. Wainberg
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 2
Purpose: To assess the response to pexidartinib treatment in six cohorts of adult patients with advanced, incurable solid tumors associated with colony-stimulating factor 1 receptor (CSF1R) and/or KIT proto-oncogene receptor tyrosine kinase activity.
Autor:
Brian A. Van Tine, Andrew J. Wagner, Javier Martin-Broto, Kazuo Tamura, William D. Tap, Robin L. Jones, Patrick Peterson, Akira Kawai, Jennifer Wright, Ashwin Shahir
Publikováno v:
Clin Cancer Res
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC. Repositorio Institucional del CSIC
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[Purpose] Few prospective studies have assessed anthracycline-associated cardiotoxicity in patients with sarcoma. We evaluated cardiotoxicity in patients with soft-tissue sarcomas administered doxorubicin in the phase III ANNOUNCE trial (NCT02451943)
Autor:
Mark T.A. Donoghue, David M. Hyman, Chaitanya Bandlamudi, William D. Tap, Sarah Chiang, Achim A. Jungbluth, Rajmohan Murali, Martee L. Hensley, Evan Rosenbaum, Robert A. Soslow, Barry S. Taylor, Preethi Srinivasan, David B. Solit, Shweta S. Chavan
Publikováno v:
Clin Cancer Res
Purpose: We examined whether prospective molecular characterization of advanced metastatic disease can reveal grade and/or histology-specific differences to inform diagnosis and facilitate enrollment onto clinical trials. Experimental Design: Patient
Autor:
Guo Gord, Zhu, Khedoudja, Nafa, Narasimhan, Agaram, Ahmet, Zehir, Ryma, Benayed, Justyna, Sadowska, Laetitia, Borsu, Ciara, Kelly, William D, Tap, Nicola, Fabbri, Edward, Athanasian, Patrick J, Boland, John H, Healey, Michael F, Berger, Marc, Ladanyi, Meera, Hameed
Publikováno v:
Clin Cancer Res
PURPOSE: Chondrosarcomas are the second most common primary malignant bone tumors. While histologic grade is the most important factor predicting the clinical outcome of chondrosarcoma, it is subject to interobserver variability. IDH1 and IDH2 hotspo
Autor:
Zarine Patel, Mrinal M. Gounder, Naoko Takebe, Mark J. Bluth, Jennifer K. Loo, Alexander N. Shoushtari, Mark A. Dickson, Leigh Gaffney, Lee Schneider, Joseph P. Erinjeri, Cristina R. Antonescu, Ana Sjoberg, Howard Streicher, William D. Tap, Ping Chi, Li-Xuan Qin, Mary Louise Keohan, Ronald P. DeMatteo, Sandra P. D'Angelo, Richard D. Carvajal
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(12)
Purpose: A phase Ib study of dasatinib plus ipilimumab in patients with gastrointestinal stromal tumor (GIST) and other sarcomas was performed on the basis of preclinical data demonstrating that combined KIT and CTLA-4 blockade is synergistic. Experi
Autor:
Fritz C. Eilber, Tibor Schuster, Wolfgang Weber, Jeffrey J. Eckardt, Matthias R. Benz, Ken Herrmann, Martin Allen-Auerbach, Michael E. Phelps, Johannes Czernin, William D. Tap, Sarah M. Dry
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 18(7)
Purpose: Neoadjuvant therapy is associated with considerable toxicity and limited survival benefits in patients with soft tissue sarcoma (STS). We prospectively evaluated whether 2[18F]fluoro-2-deoxy-d-glucose (18F-FDG)-PET/computed tomographic (CT)
Autor:
Martin Allen-Auerbach, Vladimir Evilevitch, Fritz C. Eilber, Scott D. Nelson, Jeffery J. Eckardt, Robert Elashoff, Fredrick R. Eilber, Kira Chow, Johannes Czernin, Wolfgang A. Weber, Michael E. Phelps, William D. Tap
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 14(3)
Purpose: Change in tumor size as classified by Response Evaluation Criteria in Solid Tumors poorly correlates with histopathologic response to neoadjuvant therapy in patients with soft-tissue sarcomas. The aim of this study was to prospectively evalu