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Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 28(11)
Nonmelanoma skin cancer (NMSC) is the most frequently diagnosed malignancy in humans, representing a broad range of cutaneous tumors. Keratinocyte carcinomas, including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC), are the
Autor:
Anthony J. Olszanski, Patrick M. Forde, Olivier Rixe, Yanyan Lou, Asha Nayak-Kapoor, David S. Hong, Vi K. Chiu, Floyd Fox, Margaret A. Marshall, Agron Collaku, Tomislav Dragovich, Rom Leidner, James N. Atkins
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 28(3)
Purpose: The aim of the study was to determine safety, antitumor activity, and pharmacodynamic profile of mogamulizumab, an anti-CCR4 monoclonal antibody targeting effector regulatory T cells (Treg) in combination with the checkpoint inhibitor nivolu
Autor:
Kristine S. Wong, Eleni M. Rettig, Ann Marie Egloff, Jason I. Kass, Danielle N. Margalit, Roy B. Tishler, Glenn J. Hanna, Michelle Flynn, Jochen H. Lorch, Charles T. Quinn, Megan E. Cavanaugh, Jennifer M. Cutler, Anne O'Neill, Donald J. Annino, Robert I. Haddad, Vickie Y. Jo, Ravindra Uppaluri, Cloud P. Paweletz, Kee-Young Shin, Laura A. Goguen, Jonathan D. Schoenfeld, Anupam M. Desai, Patrick H. Lizotte, Peter C. Everett, Rosh K. V. Sethi
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 28(3)
Purpose: Surgery often represents the best chance for disease control in locoregionally recurrent squamous cell carcinoma of the head and neck (SCCHN). We investigated dual immune-checkpoint inhibition [anti–PD-1, nivolumab (N), and anti-KIR, liril
Autor:
Flaminia Campo, Antonia La Malfa, Davide Renna, Emanuela Taraborelli, Maria Teresa Maccallini, Fulvia Pimpinelli, Vittoria Barberi, Martina Pontone, Paolo Carlini, Laura Conti, Aldo Morrone, Fabrizio Petrone, Virginia Ferraresi, Ludovica Gariazzo, Raul Pellini, Gianluigi Ferretti, Vincenzo Di Noia, Alessandro Monti, Diana Giannarelli, Domenico Bracco, Chiara Mandoj, Ornella Di Bella, Francesco Cognetti, Maria Di Santo
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(24)
Purpose: We assessed the immunogenicity and safety of the BNT162b2 vaccine in a large cohort of patients with cancer (CP). Experimental Design: From March 1, 2021 to March 20, 2021, this prospective cohort study included 816 CP afferent to our instit
Genome-Derived Classification Signature for Ampullary Adenocarcinoma to Improve Clinical Cancer Care
Autor:
Alice C. Wei, Efsevia Vakiani, Kevin C. Soares, Saptarshi Chakraborty, Kenneth Seier, Rohit Chandwani, T. Peter Kingham, Vinod P. Balachandran, Victoria G. Aveson, Michael I. D’Angelica, Mithat Gonen, Jeffrey A. Drebin, Brett L. Ecker, Carlie S. Sigel, William R. Jarnagin, Ronglai Shen
Publikováno v:
Clin Cancer Res
Purpose: The clinical behavior of ampullary adenocarcinoma varies widely. Targeted tumor sequencing may better define biologically distinct subtypes to improve diagnosis and management. Experimental Design: The hidden-genome algorithm, a multilevel m
Autor:
Somak Chatterjee, Martha Donoghue, Pallavi S. Mishra-Kalyani, Harpreet Singh, Erin Larkins, Hong Zhao, Missiratch Biable, Youwei Bi, Julia A. Beaver, Jiang Liu, Hisham Qosa, Richard Pazdur, Erica C Nakajima, Paz J. Vellanki, Lauren Tesh Hotaki, Yuan Li Shen
Publikováno v:
Clin Cancer Res
On October 2, 2020, FDA approved nivolumab with ipilimumab as first-line treatment for adult patients with unresectable malignant pleural mesothelioma (MPM). The approval was based on results from Study CA209743 (CHECKMATE-743), an open-label trial o
Autor:
Daniele Sommacale, Fouad Lafdil, Olivier Scatton, Hong Son Trinh, Thi Lan Tran, Christophe Tournigand, David Gentien, Isabelle Brocheriou, Van To Ta, Cong Trung Nguyen, Giuliana Amaddeo, Jean-Charles Nault, Luca Di Tommaso, Van Ky Le, Camille Boulagnon-Rombi, Stefano Caruso, Jessica Zucman-Rossi, Patrick Soussan, Manon Allaire, Jérémy Augustin, Hélène Regnault, Alain Luciani, Aurélie Beaufrère, Julien Calderaro, Valérie Paradis, Sébastien Mulé, Vincent Leroy, Frédéric Charlotte, Audrey Rapinat, Pascale Maillé, Anaïs Pujals, Raffaele Brustia, Alexis Laurent, Rami Rhaiem, Loëtitia Favre, Jean-Michel Pawlotsky
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 28(3)
Purpose: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare malignancy associated with an overall poor prognosis. We aimed to investigate the immune profile of cHCC-CCA and determine its impact on disease outcome. Experimental Design: We
Autor:
Alex Martinez-Marti, Edwin R. Parra, Bartomeu Massuti, Manuel Domine, Manuel Cobo, M. Lázaro, Nuria Viñolas, Pedro Rocha, Edel del Barco, Guillermo Lopez-Vivanco, Reyes Bernabe Caro, Miguel Barquín, Mariano Provencio, Santiago Viteri, Raquel Laza-Briviesca, Belén Sierra-Rodero, Alberto Cruz-Bermúdez, Ignacio I. Wistuba, Isidoro Barneto Aranda, Amelia Insa, Humam Kadara, Maria Rosario Garcia Campelo, Margarita Majem, M. Casarrubios, Delvys Rodriguez-Abreu, Ernest Nadal, Beatriz Sanchez-Espiridion, Javier de Castro-Carpeño, Virginia Calvo, Atocha Romero
Publikováno v:
Scientia
CLINICAL CANCER RESEARCH
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
CLINICAL CANCER RESEARCH
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Purpose:Characterization of the T-cell receptor (TCR) repertoire may be a promising source for predictive biomarkers of pathologic response to immunotherapy in locally advanced non–small cell lung cancer (NSCLC).Experimental Design:In this study, n
Autor:
Verena Kainz, Christian F. Singer, Florian Fitzal, Margaretha Rudas, Martin Filipits, Peter Regitnig, Michael Gnant, Zsuzsanna Bago-Horvath, Stephen Barron, Richard Greil, Marija Balic, Dominik Hlauschek, William M. Gallagher, Tony Loughman, Des O'Leary, Stefan Halper, Wolfgang Hulla, Peter Dubsky, Daniel Egle
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(21)
Purpose: To validate the clinical performance of the OncoMasTR Risk Score in the biomarker cohort of Austrian Breast and Colorectal Cancer Study Group (ABCSG) Trial 8. Experimental Design: We evaluated the OncoMasTR test in 1,200 formalin-fixed, para
Autor:
Isabell Schulze, Zoe Quandt, Alexander Gusev, Melinda C. Aldrich, Andrew J. Plodkowski, Mohsen Abu-Akeel, Jia Luo, Taha Merghoub, Victoria Martucci, Jacklynn V. Egger, Donglei Hu, Hira Rizvi, Matthew A. Gubens, Scott Huntsman, Megan H. Murray, Christine M. Lovly, Matthew D. Hellmann, Elad Ziv, Min Li, Stefan Groha, Eduardo Cardenas
Publikováno v:
Clin Cancer Res
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 27, iss 18
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 27, iss 18
Purpose: Genetic differences in immunity may contribute to toxicity and outcomes with immune checkpoint inhibitor (CPI) therapy, but these relationships are poorly understood. We examined the genetics of thyroid immune-related adverse events (irAE).