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pro vyhledávání: ''
Autor:
Masato Kobayashi, Kiyoshi Ariizumi, Ponciano D. Cruz, Song Zhang, Vijay Ramani, Vinita Popat, Farjana J. Fattah, David E. Gerber, Jin Sung Chung
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 26(6)
Purpose: Immune checkpoint inhibitors (ICI) benefit only a minority of treated patients with cancer. Identification of biomarkers distinguishing responders and nonresponders will improve management of patients with cancer. Because the DC-HIL checkpoi
Autor:
Mohammad O. Hoque, Hae Seong Nam, Zahra Maleki, Mariana Brait, Akira Ooki, Harvey I. Pass, Jun Chieh J. Tsay, David Sidransky, William N. Rom, Rafael Guerrero-Preston, Nitesh Turaga, Chandra Goparaju
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(22)
Purpose: To establish a novel panel of cancer-specific methylated genes for cancer detection and prognostic stratification of early-stage non–small cell lung cancer (NSCLC). Experimental Design: Identification of differentially methylated regions (
Autor:
Meng Su, Congying Xie, Hanbin Chen, Huafang Su, Deyao Xie, Xiaona Cai, Lihao Zhao, Yanfan Chen, Baochai Lin, Xiance Jin, Didi Chen, Huanle Pan, Shaoran Fei, Linger Liu, Lanxiao Shen
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(17)
Purpose: To identify tumor-derived exosomal biomarkers that are able to discriminate between adenocarcinoma and squamous cell carcinoma (SCC) as a noninvasive method in the early diagnosis of non–small cell lung cancer (NSCLC). Experimental Design:
Autor:
Vladislava O. Melnikova, Razelle Kurzrock, Hatim Husain, Scott M. Lippman, Ben Ho Park, Muneesh Tewari, Brian Woodward, Soham More, Sandeep C. Pingle, Mark G. Erlander, Elizabeth Weihe, Ezra E.W. Cohen, Karena Kosco
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 23, iss 16
Purpose: Noninvasive drug biomarkers for the early assessment of tumor response can enable adaptive therapeutic decision-making and proof-of-concept studies for investigational drugs. Circulating tumor DNA (ctDNA) is released into the circulation by
Autor:
Sarah A. Mazzilli, Marc E. Lenburg, Mary E. Reid, Samjot Singh Dhillon, Anna Tassinari, Stephen Lam, Gang Liu, Hanqiao Liu, Xiaohui Zhang, Avrum Spira, Suso Platero, Jennifer Beane, Anne Dy Buncio
Publikováno v:
Clin Cancer Res
Purpose: Lung cancer is the leading cause of cancer-related death in the United States. The molecular events preceding the onset of disease are poorly understood, and no effective tools exist to identify smokers with premalignant lesions (PMLs) that
Autor:
Jill Walker, Marietta Scott, Hytham Al-Masri, Marlon Rebelatto, Alan Sharpe, Craig Barker, Paul Scorer, Anita Midha, Marianne Ratcliffe
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(14)
Purpose: Immunotherapies targeting programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) demonstrate encouraging antitumor activity and manageable tolerability in non–small cell lung cancer (NSCLC), especially in patients with h
Autor:
Kiyotaka Yoh, Shigeki Umemura, Shingo Matsumoto, Yuki Matsumura, Hironobu Ohmatsu, Tomohiro Miyoshi, Katsuya Tsuchihara, Tomoyuki Hishida, Masahiro Tsuboi, Hideki Makinoshima, Koichi Goto, Satoshi Tada, Keiju Aokage, Junji Yoshida, Sachiyo Mimaki, Seiji Niho, Genichiro Ishii, Kanji Nagai, Hibiki Udagawa
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(3)
Purpose: Although large-cell neuroendocrine carcinoma (LCNEC) of the lung shares many clinical characteristics with small-cell lung cancer (SCLC), little is known about its molecular features. We analyzed lung LCNECs to identify biologically relevant
Autor:
Hongwei Wang, Murray J. Favus, Hui Yun Wang, Xiaomin Niu, Shun Lu, Rongrong Wei, Hengying Pu, Xiaoling Weng, Yonglan Zheng, Yi Xin Zeng, Lan Cao, Lan-Jun Zhang, Wanqing Liu, Wei Hua Jia, Yun Liu, Hong Zhang, Christopher I. Amos
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 21(22)
Purpose: EGF receptor (EGFR) mutation–positive (EGFRmut+) non–small cell lung cancer (NSCLC) may be a unique orphan disease. Previous studies suggested that the telomerase reverse transcriptase (TERT) gene polymorphism is associated with demograp
Autor:
Anna Karlsson, Maria Planck, Markus Ringnér, Mats Jönsson, Göran Jönsson, Hans Brunnström, Åke Borg, Martin Lauss, Johan Staaf, Per Jönsson
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 20(23)
Purpose: Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. However, whether clinically relevant subgroups based
Autor:
Magali Olivier, Maxime Vallée, P. Missy, Tibor Schuster, Felipe Vaca-Paniagua, Bernard Duvert, Hélène Blanché, Jacques Margery, Pascal Foucher, Sébastien Larivé, Gérard Zalcman, Nicolas Girard, James McKay, Radj Gervais, Stephanie Villar, Nathalie Prim, Javier Oliver, Laurent Guilleminault, Sébastien Couraud, Michel Vincent, Jean Trédaniel, Florence Le Calvez-Kelm, Pierre-Jean Souquet, Franck Morin
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 20(17)
Purpose: Tumor somatic mutation analysis is part of the standard management of metastatic lung cancer. However, physicians often have to deal with small biopsies and consequently with challenging mutation testing. Circulating free DNA (cfDNA) is a pr