Zobrazeno 1 - 10
of 20
pro vyhledávání: ''
Autor:
Winston W. Huh, Eric M. Rohren, Kalevi Kairemo, Najat C. Daw, Homer A. Macapinlac, Joseph A. Ludwig, David S. Hong, Vivek Subbiah, Peter M. Anderson, Sant P. Chawla, Eugenie S. Kleinerman, Robert S. Benjamin, Vinod Ravi, Funda Meric-Bernstam, Gregory Ravizzini, Kenneth R. Hess, Neeta Somaiah
Publikováno v:
Clin Cancer Res
Purpose: The prognosis of metastatic osteosarcoma continues to be poor. We hypothesized that alpha-emitting, bone-targeting radium 223 dichloride (223RaCl2) can be safely administered to patients with osteosarcoma and that early signals of response o
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 24(22)
Purpose: To explore the molecular mechanism and prognosis of bone-invasive pituitary adenomas (BIPA). Experimental design: A total of 274 patients with pituitary adenomas were followed up. Transcriptomic microarrays analysis was performed on 10 pitui
Autor:
Myung Shin-Sim, Jeffrey E. Gershenwald, Jason Roszik, Keiji Tanese, Dave S.B. Hoon, Donald L. Morton, Denái R. Milton, Elizabeth A. Grimm, Michael A. Davies, Victor G. Prieto, Scott E. Woodman, Suhendan Ekmekcioglu, Roland L. Bassett
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 22(12)
Purpose: Inflammatory marker expression in stage III melanoma tumors was evaluated for association with outcome, using two independent cohorts of stage III melanoma patients' tumor tissues. Experimental Design: Fifteen markers of interest were select
Autor:
Paolo Corradini, Laura Giordano, Alessandro M. Gianni, Massimo Di Nicola, Lucia Farina, Simonetta Viviani, Alfonso Marchianò, Roberto Sorasio, Anna Guidetti, Walter Malorni, Carmelo Carlo-Stella, Domenico Russo, Andrea Anichini, Roberta Mortarini, Silvia L. Locatelli, Anna Dodero
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 20(22)
Purpose: To evaluate safety and activity of perifosine and sorafenib combination therapy in patients with lymphoproliferative diseases. Experimental Design: Patients with relapsed and refractory lymphoproliferative diseases received perifosine (50 mg
Autor:
Robert B. Diasio, Steven R. Alberts, Qian Shi, Adam M. Lee, Frank A. Sinicrope, Daniel J. Sargent, Dan Sha
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 20(12)
Purpose: A let-7 microRNA-complementary site (LCS6) polymorphism in the 3′ untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression. We evaluated the LCS6 genotype and its association with KRAS mut
Autor:
Yvonne Saenger, John M. Kirkwood, Sara Harcharik, Jay Magidson, Karl Wassmann, Yichun Fu, Bobby Chi-Hung Liaw, Ellen H de Moll, Philip Friedlander, David E. Fisher, William Oh
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 20(12)
Purpose: Tremelimumab (ticilimumab, Pfizer), is a monoclonal antibody (mAb) targeting cytotoxic T lymphocyte–associated antigen-4 (CTLA-4). Ipilimumab (Yervoy, BMS), another anti-CTLA-4 antibody, is approved by the U.S. Federal Drug Administration
Autor:
Marius E. Mayerhoefer, Werner Dolak, Kurt Kletter, Helmut Prosch, Dominik Berzaczy, Martha Hoffmann, Edit Porpaczy, Markus Raderer, Christian Sillaber, Julius Lukas, Philipp Ubl, Katja Pinker-Domenig, Cathrin Skrabs, Michael Weber, Leonhard Müllauer, Barbara Kiesewetter, Alexander Gaiger, Ingrid Simonitsch-Klupp, Georgios Karanikas, Ulrich Jaeger
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 20(11)
Purpose: To determine the value of diffusion-weighted MRI (DWI-MRI) for pretherapeutic imaging of fluorodeoxyglucose (FDG)-avid lymphoma and lymphoma with variable FDG avidity. Experimental Design: Treatment-naïve patients with lymphoma who were ref
Autor:
Zhihong Chi, Bixia Tang, Lili Mao, Siming Li, Xinan Sheng, Lu Si, Bin Lian, Yan Kong, Chuanliang Cui, Jun Guo
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 19(16)
Purpose: Mucosal melanoma is rare and associated with extremely poor prognosis. However, standard adjuvant therapy for mucosal melanoma has not been established. We conducted a randomized phase II clinical trial in patients with resected mucosal mela
Autor:
Arnold J. Levine, Yi-Chieh Nancy Du, Murray F. Brennan, Chris R. Harris, Laura H. Tang, Peter J. Allen, David S. Klimstra, Richard Clausen, Tanupriya Contractor
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 18(17)
Purpose: In mice, genetic changes that inactivate the retinoblastoma tumor suppressor pathway often result in pancreatic neuroendocrine tumors (Pan-NETs). Conversely, in humans with this disease, mutations in genes of the retinoblastoma pathway have
Autor:
Katja, Harbst, Johan, Staaf, Martin, Lauss, Anna, Karlsson, Anna, Måsbäck, Iva, Johansson, Pär-Ola, Bendahl, Johan, Vallon-Christersson, Therese, Törngren, Henrik, Ekedahl, Jürgen, Geisler, Mattias, Höglund, Markus, Höglund, Markus, Ringnér, Mattias, Ringnér, Lotta, Lundgren, Karin, Jirström, Håkan, Olsson, Christian, Ingvar, Åke, Borg, Hensin, Tsao, Göran, Jönsson
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 18(15)
Purpose: For primary melanomas, tumor thickness, mitotic rate, and ulceration are well-laid cornerstones of prognostication. However, a molecular exposition of melanoma aggressiveness is critically missing. We recently uncovered a four-class structur