Zobrazeno 1 - 10
of 45
pro vyhledávání: ''
Autor:
Pingfu Fu, Monaliben Patel, John J. Pink, Tithi Biswas, Mitchell Machtay, Shufen Cao, Charles A Kunos, Debora S. Bruno, Stanton L. Gerson, David L. Bajor, Nancy L. Oleinick, Shakun Malik, Afshin Dowlati
Publikováno v:
Clin Cancer Res
Purpose: TRC102, a small-molecule base-excision repair inhibitor, potentiates the cytotoxicity of pemetrexed and reverses resistance by binding to chemotherapy-induced abasic sites in DNA. We conducted a phase I clinical trial combining pemetrexed an
Autor:
Phillip L. Palmbos, Przemyslaw Twardowski, Vivek K. Arora, Alicia K. Morgans, Dan R. Robinson, Karen E. Knudsen, Matthew S. Davenport, Maha Hussain, Neeraj Agarwal, Javed Siddiqui, Emmanuel S. Antonarakis, Jon A. Jacobson, Stephanie Daignault-Newton, Scott A. Tomlins, Wm. Kevin Kelly, Arul M. Chinnaiyan
Publikováno v:
Clin Cancer Res
Purpose: Palbociclib, a cyclin-dependent kinase (CDK) 4/6 inhibitor, blocks proliferation in a RB and cyclin D–dependent manner in preclinical prostate cancer models. We hypothesized that cotargeting androgen receptor and cell cycle with palbocicli
Autor:
Seth P. Lerner, Bruno R. Bastos, Dan Theodorescu, Jared S. Fowles, Thomas W. Flaig, Amir Goldkorn, Catherine M. Tangen, Daniel L. Gustafson, Rick Bangs, M. Scott Lucia, Gary R. MacVicar, David J. McConkey, Melissa Plets, Matthew I. Milowsky, Siamak Daneshmand, Ajjai Alva, Ian M. Thompson
Publikováno v:
Clin Cancer Res
Purpose: Dose-dense methotrexate-vinblastine-adriamycin-cisplatin (ddMVAC) and gemcitabine-cisplatin (GC) are accepted neoadjuvant regimens for muscle-invasive bladder cancer. The aim of this study was to validate the score from a coexpression extrap
Autor:
Ash A. Alizadeh, Douglas J. Jolly, Harry E. Gruber, Aaron M. Newman, Maximilian Diehn, Dawn Gammon, Ali Haghighi, William P. Accomando, Daniel J. Hogan, Aki Nakao, Aliz R. Rao, Oscar Diago, Derek Ostertag
Publikováno v:
Clinical Cancer Research. 26:6176-6186
Purpose: High-grade gliomas (HGGs) are central nervous system tumors with poor prognoses and limited treatment options. Vocimagene amiretrorepvec (Toca 511) is a retroviral replicating vector encoding cytosine deaminase, which converts extended relea
Autor:
Z Yang, Arlene Chan, Pierfranco Conte, Sara M. Tolaney, Thomas Bachelot, Yanyun Chen, Nan Lin, Véronique Diéras, Peter Kabos, Ahmad Awada, Carey K. Anders, Melissa M. Bear, Solmaz Sahebjam, Denise A. Yardley, Emilie Le Rhun, Sonya C. Chapman
Publikováno v:
Clinical Cancer Research. 26:5310-5319
Purpose:The primary objective was to evaluate intracranial objective response rate (iORR) in patients receiving abemaciclib with brain or leptomeningeal metastases (LM) secondary to hormone receptor–positive (HR+) metastatic breast cancer (MBC). Se
Autor:
Xianglin Yuan, Xiang Li, Buhai Wang, Nong Xu, Jian-Ming Xu, Jin Wang, Enxiao Li, Yuxian Bai, Xin Wang
Publikováno v:
Clinical Cancer Research. 26:4542-4550
Purpose: This phase II study (NCT03469557) assessed safety/tolerability and antitumor activity of first-line tislelizumab, a monoclonal antibody against programmed cell death-1, plus chemotherapy in patients with locally advanced/metastatic esophagea
Autor:
Annette Fontaine, Anup Kasi, Jourdain Hayward, Tareq Al Baghdadi, Manisha Shah, Melissa Plets, Megan Othus, Razelle Kurzrock, Edward Mayerson, Zoran Gatalica, Francis J. Giles, Christopher W. Ryan, Donna E. Hansel, Christine M. McLeod, Sandip Pravin Patel, Elad Sharon, Helen X. Chen, Marc Matrana, W. Michael Korn, Preet Paul Singh, Young Kwang Chae, Charles D. Blanke
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 26, iss 10
Clin Cancer Res
Clin Cancer Res
Purpose: Immune checkpoint blockade has improved outcomes across tumor types; little is known about the efficacy of these agents in rare tumors. We report the results of the (nonpancreatic) neuroendocrine neoplasm cohort of SWOG S1609 dual anti–CTL
Autor:
Samip Patel, Benjamin G. Vincent, Juneko E. Grilley Olson, D. Neil Hayes, Jessica Bauman, Mark C. Weissler, Bhishamjit S. Chera, Karen P. McKinnon, Thomas J. Galloway, Hsing-Hui Wang, Allision M. Deal, Siddharth Sheth, Jared Weiss, Christopher E. Hilliard, S. Patel, Adam M. Zanation, Ranee Mehra, Colette J. Shen, Jeffrey M. Blumberg, Trevor Hackman
Publikováno v:
Clin Cancer Res
Purpose: Although cisplatin plus radiotherapy is a standard treatment of locally advanced head and neck squamous cell carcinoma (LA-HNSCC), cisplatin contraindication is common. Radiation elicits and promotes tumor-directed immune stimulation, which
Autor:
Andrew J. Plodkowski, Daniel C. McFarland, Miguel A. Villalona-Calero, Mark G. Kris, John J. Fiore, Juliana Eng, Rachel Kim, Ai Ni, Afsheen Iqbal, Charles M. Rudin, Philip Jonsson, Paul K. Paik, Mark T.A. Donoghue, Linda Ahn, Kenneth K. Ng
Publikováno v:
Clin Cancer Res
Purpose: Gemcitabine and albumin-bound paclitaxel (ABP) exhibit synergistic antitumor efficacy, with ABP serving to increase the intratumoral gemcitabine concentration. Both drugs are active in squamous cell lung cancers (SQCLC) and are conventional
Autor:
Joel G. Turner, Alan F. List, Christopher L. Cubitt, Jeffrey E. Lancet, Julio C. Chavez, Bijal D. Shah, Kendra Sweet, Daniel M. Sullivan, Eric Padron, Rami S. Komrokji, Jana L. Dawson, David A. Sallman, Junmin Zhou
Publikováno v:
Clin Cancer Res
Purpose: Induction chemotherapy results in complete remission (CR) rates of 20% to 50% among patients with poor-risk AML. Selinexor is an oral selective inhibitor of nuclear export with promising single-agent activity. By inhibiting the primary expor