Zobrazeno 1 - 10
of 1 860
pro vyhledávání: ''
Autor:
Emmy W. Verschuren, Pekka Paivinen, Sushil Tripathi, Ashwini S. Nagaraj, Eva Domenech-Moreno, Tomi P. Mäkelä, Kari Vaahtomeri, Iris P. L. Wong, Sarang S. Talwelkar, Marc Foretz, Benoit Viollet, Yan Yan, Yajing Gao
Publikováno v:
Clinical Cancer Research
Clinical Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Purpose: Mutations in STK11 (LKB1) occur in 17% of lung adenocarcinoma (LUAD) and drive a suppressive (cold) tumor immune microenvironment (TIME) and resistance to immunotherapy. The mechanisms underpinning the establishment and maintenance of a cold
Autor:
Sunil J. Advani, Hyunho Yoon, Rowan Ustoy, Mayra Yebra, Vipul R. Sheth, Sudeep Banerjee, Michael Heinrich, Christian M. Metallo, Joseph A. Aguilera, Sangkyu Noh, Scott M. Lippman, Razelle Kurzrock, Chih-Min Tang, Olivier Harismendy, Paul T. Fanta, Adam M. Burgoyne, Avi Kumar, Thekla Cordes, Shruti Bhargava, Sam Li, Jason K. Sicklick, Christopher L. Corless
Publikováno v:
Clin Cancer Res
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 1
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 1
Purpose: Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract, with mutant succinate dehydrogenase (SDH) subunits (A–D) comprising less than 7.5% (i.e., 150–200/year) of new cases annually in the United S
Autor:
Lakshmi Muthuswamy, Ling Huang, Raul S. Gonzalez, Jonah Cohen, Senthil K. Muthuswamy, Catherine Conahan, Supraja Narasimhan, Tyler M. Berzin, Mandeep S. Sawhney, Andrea J. Bullock, Mary Linton B. Peters, Sofia Perea, Roger B. Davis, Benjamin Schlechter, Bruno Bockorny, Dipikaa Akshinthala, Robert J. Besaw, Mark P. Callery, Douglas K. Pleskow, Leo L. Tsai, Martin P. Smith, Christine Maria Lim, Manuel Hidalgo, Tara S. Kent, Joseph E. Grossman
Publikováno v:
Clin Cancer Res
Purpose: Pancreatic ductal adenocarcinoma (PDAC) remains a significant health issue. For most patients, there are no options for targeted therapy, and existing treatments are limited by toxicity. The HOPE trial (Harnessing Organoids for PErsonalized
Autor:
Martin Gotthardt, J. Fred Verzijlbergen, Jean-Paul A. van Basten, Melline G.M. Schilham, James Nagarajah, Robert Jan Smeenk, Sandra Heskamp, J. Alfred Witjes, Steffie M. B. Peters, Tom W. J. Scheenen, Marcel J.R. Janssen, Inge M. van Oort, Maike J. M. Uijen, Jelle O. Barentsz, Niven Mehra, Michiel Sedelaar, Bastiaan M. Privé, Diederik M. Somford, Constantijn H.J. Muselaers, Annemarie Eek, Winald R. Gerritsen, Linda G W Kerkmeijer, Mark Konijnenberg, Patrik Zamecnik
Publikováno v:
Clinical Cancer Research, 27, 13, pp. 3595-3601
Clinical Cancer Research, 27, 3595-3601
Clinical Cancer Research, 27(13), 3595-3601. American Association for Cancer Research Inc.
Clinical Cancer Research, 27, 3595-3601
Clinical Cancer Research, 27(13), 3595-3601. American Association for Cancer Research Inc.
Purpose: [177Lu]Lu-PSMA-617 radioligand therapy (177Lu-PSMA) is a novel treatment for metastatic castration-resistant prostate cancer (mCRPC), which could also be applied to patients with metastatic hormone-sensitive prostate cancer (mHSPC) with PSMA
Publikováno v:
Clinical Cancer Research. 27:3499-3502
[][1] Breast cancer continues to register one of the most common incidence and deaths among female cancers. However, during the last three decades, breast cancer treatment benefited from a sea-change for specific subtypes. These successes led to incr
Autor:
Wuping Tang, Yi Li, Wei Zhou, Jinhui Hu, Bin Dai, Liyuan Qian, Hui Zhang, Zhi Xiao, Jianguo Wang, Tao Wu, Shouman Wang, Yunqi Wang, Q. Chen, Tiegang Tang, Xiaohong Yang, Jie Weng, Munawar Anwar, Dengjie Ouyang, Liping Liu, Peizhi Fan, Ning Xie, Maoliang Xiao, Xiaowen Gu, Jing Li, Bo Qiu, Zhongming Wang, Quchang Ouyang, Shan Zeng, Enxiang Zhou, Wenjun Yi, Chao Deng, Hailong Liu, Xiantao Li, Boning Ding, Lai Li, Lei Guo, Mingwen Liu, Gannong Chen
Publikováno v:
Clinical Cancer Research. 27:4634-4641
Purpose: Patients with HER2-positive (HER2+) metastatic breast cancer (MBC) have poor prognoses. Pyrotinib has shown promising antitumor activity in MBC to improve progression-free survival (PFS). However, findings based on real-world data to analyze
Autor:
Richard van Hillegersberg, Tom van den Ende, Sybren L. Meijer, Rob H.A. Verhoeven, Max Nieuwdorp, Mark P. G. Dings, Nadia Haj Mohammad, Tanja D. de Gruijl, Nicolien C. de Clercq, H.W.M. van Laarhoven, Jacques J. Bergman, Elisabeth D. Geijsen, Stella Mook, Sandor Schokker, Maarten C.C.M. Hulshof, Nicole C.T. van Grieken, Maarten F. Bijlsma, Bauke Ylstra, Jelle P. Ruurda, Mark I. van Berge Henegouwen, Suzanne S. Gisbertz, Tanya T.D. Soeratram
Publikováno v:
van den Ende, T, Clercq, N D, van Berge Henegouwen, M I, Gisbertz, S S, Geijsen, D, Verhoeven, R, Meijer, S L, Schokker, S, Dings, M, Bergman, J J G H M, Haj Mohammad, N, Ruurda, J P, van Hillegersberg, R, Mook, S, Nieuwdorp, M, de Gruijl, T D, Soeratram, T T D, Ylstra, B, van Grieken, N C T, Bijlsma, M F, Hulshof, M C C M & van Laarhoven, H W 2021, ' Neoadjuvant Chemoradiotherapy Combined with Atezolizumab for Resectable Esophageal Adenocarcinoma : A Single Arm Phase II Feasibility Trial (PERFECT) ', Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 27, no. 12, pp. 3351-3359 . https://doi.org/10.1158/1078-0432.CCR-20-4443
Clinical cancer research : an official journal of the American Association for Cancer Research, 27(12), 3351-3359. American Association for Cancer Research Inc.
Clinical cancer research, 27(12), 3351-3359. American Association for Cancer Research Inc.
Clin Cancer Res
Clinical cancer research : an official journal of the American Association for Cancer Research, 27(12), 3351-3359. American Association for Cancer Research Inc.
Clinical cancer research, 27(12), 3351-3359. American Association for Cancer Research Inc.
Clin Cancer Res
Purpose: The CROSS trial established neoadjuvant chemoradiotherapy (nCRT) for patients with resectable esophageal adenocarcinoma (rEAC). In the PERFECT trial, we investigated the feasibility and efficacy of nCRT combined with programmed-death ligand-
Autor:
Young Suk Park, Peter G. Mortimer, Kyoung-Mee Kim, Sophie E. Willis, Emma Dean, Claire Smith, Jung Yong Hong, Itziar Irurzun-Arana, Arsene-Bienvenu Loembé, Joon Oh Park, Iwanka Kozarewa, Andrew J. Pierce, Jeeyun Lee, Ho Yeong Lim, Simon Smith, Alienor Berges, Won Ki Kang, Hee Jin Cho, Seung Tae Kim, Se Hoon Park
Publikováno v:
Clinical Cancer Research. 27:4700-4709
Purpose: Ceralasertib is a potent and selective oral inhibitor of the serine/threonine protein kinase ataxia telangiectasia and Rad3-related (ATR) protein. Patients and Methods: Eligible patients with solid tumors, enriched for melanoma, received cer
Autor:
Vinod P. Balachandran, James J. Harding, Andrea Cercek, Michael I. D’Angelica, William R. Jarnagin, Louise Catherine Connell, Joshua S. Jolissaint, T. Peter Kingham, Kevin C. Soares, Kenneth Seier, Mithat Gonen, Nancy E. Kemeny, Ramyasree Madupuri, Ritika Kundra, Alice C. Wei, Thomas Boerner, Jeffrey A. Drebin, Carlie S. Sigel, Paul Shin, Efsevia Vakiani
Publikováno v:
Clin Cancer Res
Purpose: Lymph node metastasis (LNM) drastically reduces survival after resection of intrahepatic cholangiocarcinoma (IHC). Optimal treatment is ill defined, and it is unclear whether tumor mutational profiling can support treatment decisions. Experi
Autor:
Troy Bremer, Jonas Bergh, Dick Folkvaljon, Lars A. Akslen, Fredrik Wärnberg, Viktoria Thurfjell, Arne Östman, Erik Holmberg, Per Karlsson, Aglaia Schiza, Carina Strell
Publikováno v:
Clinical Cancer Research. 27:3469-3477
Purpose: This study analyzes the potential of stromal platelet-derived growth factor receptor-beta (PDGFRb) expression as biomarker for radiotherapy (RT) benefit on ipsilateral breast events (IBE) in ductal carcinoma in situ (DCIS). Improved identifi