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Publikováno v:
Clinical and Vaccine Immunology. 23:417-426
Cryopreserved peripheral blood mononuclear cells (PBMCs) are widely used in studies of dengue. In this disease, elevated frequency of apoptotic PBMCs has been described, and molecules such as soluble tumor necrosis factor (TNF)-related apoptosis-indu
Publikováno v:
Clinical and Vaccine Immunology. 23:162-167
The efficacy of the serotype 3 (ST3) pneumococcal conjugate vaccine (PCV) remains unclear. While the synthesis of capsular polysaccharide (CPS) of most serotypes is wzy dependent, the strains of two serotypes, 3 and 37, synthesize CPS by the synthase
Autor:
Howard M. Johnson, Chulbul M. Ahmed
Publikováno v:
Clinical and Vaccine Immunology. 21:1178-1184
The canonical model of interferon (IFN) signaling focuses solely on the activation of STAT transcription factors which, according to the model, are initiated by the singular event of cross-linkage of the receptor extracellular domain by the IFN. The
Publikováno v:
Clinical and Vaccine Immunology. 20:262-268
Cockroach allergen is a major risk factor for IgE-mediated allergic response and asthma in sensitized individuals. Serine proteases have been identified from various sources and characterized as major allergens. The present study was aimed to express
Autor:
Diane M Spencer, David S. Pisetsky
Publikováno v:
Clinical and Vaccine Immunology. 18:1420-1426
Microparticles (MPs) are small membrane-bound vesicles that display proinflammatory and prothrombotic properties. These particles can be released by macrophages stimulated by ligands of the Toll-like receptors (TLRs) in a process that depends on nitr
Publikováno v:
Clinical and Vaccine Immunology. 15:303-307
The combined adjuvant effect of ginsenoside Rg1 and aluminum hydroxide (alum) on immune responses to ovalbumin (OVA) in mice was investigated. BALB/c mice were subcutaneously (s.c.) inoculated twice with OVA alone or in combination with Rg1, alum, or
Autor:
Jeffrey G. Smith, Tina Green, Melissa Wooters, Jodie A. Field, Robin M. Kaufhold, Joseph M. Antonello, Heather R. Joseph, Michael J. Caulfield
Publikováno v:
Clinical and Vaccine Immunology. 14:527-537
The enzyme-linked immunospot (ELISPOT) assay is a powerful tool for measuring antigen-specific cellular immune responses. The ability to use frozen peripheral blood mononuclear cells (PBMC) facilitates testing samples in multicenter clinical trials;
Publikováno v:
Clinical and Vaccine Immunology. 14:348-354
Human immunodeficiency virus type 1 (HIV-1)-specific cellular immune responses are elicited in a proportion of infants born to HIV-1-infected mothers and are associated with protection against vertical transmission. To investigate correlates of these
Publikováno v:
Clinical and Vaccine Immunology. 13:349-355
The potentially protective role of the host adrenal-glucocorticoid response to enterococcal infection was evaluated in an experimental model in which mice were infected intraperitoneally with two distinctEnterococcus faecalisstrains (K9 and CP-1). We
Publikováno v:
Clinical and Vaccine Immunology. 12:1322-1327
The performance of different in vitro diagnostic tests for the diagnosis of invasive aspergillosis (IA) was investigated in a transiently neutropenic rat model. Rats were immunosuppressed with cyclophosphamide and then inoculated intravenously with 1