Zobrazeno 1 - 10
of 122
pro vyhledávání: ''
Autor:
Terrance P. Snutch, Changiz Taghibiglou, Sathiya Sekar, John G. Howland, Venkat Gopalakrishnan, Quentin Greba, Wendie N. Marks
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 47:1530-1536
Insulin-mediated signalling in the brain is critical for neuronal functioning. Insulin resistance is implicated in the development of some neurological diseases, although changes associated with absence epilepsy have not been established yet. Therefo
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 40:795-802
Suboptimal conditions in utero are associated with the development of adult-onset diseases in offspring. Uteroplacental insufficiency in rats is a well-established animal model used to mimic and study the effects of developmental insults relevant to
Autor:
Christina Y.R. Tan, Steven C. Zammit, Darren J. Kelly, Bing Hui Wang, Yuan Zhang, Sih Min Tan, Henry Krum, Spencer J. Williams
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 39:650-656
Diabetic cardiomyopathy is characterized by early diastolic dysfunction and structural changes, such as interstitial fibrosis and cardiac hypertrophy. Using the Ren-2 rat model, we sought to investigate the effect of FT23 on the structural and functi
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 19:531-535
SUMMARY The present study was designed to investigate the presynaptic α2-adrenoceptor function to inhibit norepinephrine (NE) release in blood vessels of reduced renal mass salt hypertensive rats (Na-loaded HT). Isolated perfused mesenteric vasculat
Autor:
Shane L. Carney
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 19:433-438
1. Because in vitro adenylate cyclase activity studies suggest that parathyroid hormone (PTH) and calcitonin (CT) increase renal tubular calcium and magnesium reabsorption by stimulating the same transport mechanism, the separate and combined effects
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 19:439-445
1. Serum, tissue and urine angiotensin I-converting enzyme (ACE) activity was estimated in the following groups of rats: saline-injected rats (controls); captopril-treated (CAP) control animals (CONTROL-CAP); puromycin aminonucleoside (PAN)-induced n
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 19:361-364
SUMMARY 1. The aim of this study was to develop non-invasive echocardiography methods of measuring left ventricular mass (LVM) in rats, and to determine their usefulness in detecting left ventricular hypertrophy. 2. After initial studies to identify
Autor:
Colin I. Johnston, Yoshiharu Murohara
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 19:380-383
SUMMARY 1. The acute hormonal, renal and haemodynamic effects of SCH 39370, a new neutral endopeptidase (NEP) inhibitor, were evaluated in rats with congestive heart failure (CHF) produced by coronary ligation. 2. Left ventricular systolic pressure a
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 19:353-357
1. ACE from rat lung and testis was characterized by radioligand binding studies using [125I]-Ro 31-8472, the radioiodinated hydroxy derivative of the potent ACE inhibitor cilazaprilat. 2. Analysis of the displacement of [125I]-Ro 31-8472 from ACE by
Autor:
Hans R. Brunner, Eric Grouzmann, Philippe Walker, Jean-François Aubert, Bernard Waeber, Jürg Nussberger
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 19:223-228
SUMMARY 1. (1-36)-NPY is a vasoconstrictor peptide widely distributed in sympathetic nerve terminals. This peptide exerts an inhibitory action on renin release induced by various stimuli. Post-synaptic neuropeptide Y (NPY) receptors show a high affin