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Autor:
Jie Ji, Jielu Liu, Suado M. Abdillahi, Malin Noreby, Henric Olsson, Sven-Erik Dahlén, Gunnar Nilsson, Mikael Adner, Patricia Ramos-Ramírez
Publikováno v:
Clinical & Experimental Allergy. 50:1184-1195
Background Animal models are extensively used to study underlying mechanisms in asthma. Guinea pigs share anatomical, pharmacological and physiological features with human airways and may enable the development of a pre-clinical in vivo model that cl
Autor:
Tetsuji Takabayashi, David B. Conley, Robert C. Kern, Shigeharu Fujieda, Kathryn E. Hulse, Leslie C. Grammer, Yoshimasa Imoto, Kathleen E. Harris, Atsushi Kato, Whitney W. Stevens, Anju T. Peters, James E. Norton, Bruce K. Tan, Robert P. Schleimer, Masafumi Sakashita, Lydia Suh, Roderick G. Carter, Ava R. Weibman, Kevin C. Welch
Publikováno v:
Clinical & Experimental Allergy. 48:544-554
Background Chronic rhinosinusitis (CRS) is a heterogeneous chronic inflammatory disease generally divided based on the presence or absence of nasal polyps (NPs). One of the features of NPs is excessive fibrin deposition, which is associated with down
Autor:
Willem A. Dik, P. Martin van Hagen, Conny van Holten-Neelen, Benjamin Schrijver, Roy Gerth van Wijk, Paul L A van Daele, M. A. W. Hermans
Publikováno v:
Clinical & Experimental Allergy, 48(11), 1412-1420. Wiley-Blackwell Publishing Ltd
Background: Mastocytosis is characterized by the accumulation of aberrant mast cells (MC). Patients suffering from mastocytosis suffer from a wide range of symptoms due to increased levels of MC mediators. It would therefore be of great benefit to in
Autor:
Eugene Haydn Walters, S Weston, A. K. Y. Teoh, S. M. Lam, David W. Reid, Y. H. Khor, D. C. Q. Mo
Publikováno v:
Clinical & Experimental Allergy. 39:1659-1667
Summary Background Airway microcirculation is abnormal in asthma but the role of vascular changes in asthma deteriorations remains poorly defined. We prospectively assessed the vascular changes accompanying worsening of asthma control by using an inh
Publikováno v:
Clinical & Experimental Allergy. 38:659-666
Summary Background Acute stress affects a variety of organs and cellular systems. These include the hypothalamic–pituitary–adrenal (HPA) axis, corticotropin-releasing factor (CRF), mast cells and nerves. Flinders-sensitive (FSL) rat strains have
Autor:
Otto Scheiner, Krisztina Szalai, Julia Wallmann, Tamara Kopp, Erika Jensen-Jarolim, P. Karagiannis, Isabella Pali-Schöll, Richard Brunner
Publikováno v:
Clinical & Experimental Allergy. 37:1566-1573
Summary Background Recently we have shown that anti-acid drugs lead to an enhanced risk of food allergy. This may be due to hindered peptic digestion, caused by an elevation of the gastric pH. Additionally, it is known that aluminium-linked antigens
Autor:
Yasuto Kondo, R. Komatsubara, Yoichi Nakajima, Makiko Kawamura, Atsuo Urisu, K. Yamada, Reiko Tokuda, Michiko Kakami, Ikuya Tsuge
Publikováno v:
Clinical & Experimental Allergy. 36:1538-1545
Summary Background The role of antigen-specific T cells in the allergic reaction to cow's milk or in tolerance induction is not yet fully understood. Objective This study was designed to analyse both cow's milk protein (CMP)-specific T cell prolifera
Publikováno v:
Clinical & Experimental Allergy. 33:1555-1560
Background It is well-known that FK506 strongly inhibits cytokine production by T cells in vitro. However, less evidence is available from in vivo studies of ocular allergy. Objective To study the anti-inflammatory effect of FK506 eye drops on late a
Autor:
H. Mechiche, L. Candenas, F. M. Pinto, P. Devillier, P. Birembault, Charles Advenier, Emmanuel Naline
Publikováno v:
Clinical & Experimental Allergy. 33:887-894
Summary Background Evidence suggests that small airways contribute to clinically significant processes in asthma. Cysteinyl leukotrienes (CysLTs) are considered to be pivotal mediators in the pathogenesis of asthma. Montelukast (MK), a specific CysLT
Publikováno v:
Clinical & Experimental Allergy. 33:802-807
Background Pranlukast is a leukotriene 1 (LT1) receptor antagonist and is effective against bronchial asthma. Pranlukast inhibits contraction of the tracheal muscle, and thereby antagonizes the binding of LTC4, LTD4 and LTE4. However, the action of p