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Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide
Autor:
Christopher D. Kontos, Asif Ahmed, Jianhua Huang, Xi-Lin Niu, Peter W. Hewett, Rahul Potluri, Takeshi Fujisawa, Kunal Chudasama, Melissa J. Cudmore, Bahjat Al-Ani, Clarence M. Findley, Allyah Abbas, Shakil Ahmad, Vineet Bhandari, Gregory K.W. Lam
Publikováno v:
Ahmed, A, Fujisawa, T, Niu, X-L, Ahmad, S, Al-Ani, B, Chudasama, K, Abbas, A, Potluri, R, Bhandari, V, Findley, C M, Lam, G K W, Huang, J, Hewett, P W, Cudmore, M & Kontos, C D 2009, ' Angiopoietin-2 confers Atheroprotection in apoE-/-mice by inhibiting LDL oxidation via nitric oxide ', Circulation Research, vol. 104, no. 12, pp. 1333-6 . https://doi.org/10.1161/CIRCRESAHA.109.196154
Atherosclerosis is promoted by a combination of hypercholesterolemia and vascular inflammation. The function of Angiopoietin (Ang)-2, a key regulator of angiogenesis, in the maintenance of large vessels is unknown. A single systemic administration of