Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ping Xiao"'
Autor:
Fengxiang Lv, Yingfan Wang, Dan Shan, Sile Guo, Gengjia Chen, Li Jin, Wen Zheng, Han Feng, Xiaohu Zeng, Shuo Zhang, Yan Zhang, Xinli Hu, Rui-Ping Xiao
Publikováno v:
Circulation Research. 131:962-976
Background: As an integral component of cell membrane repair machinery, MG53 (mitsugumin 53) is important for cardioprotection induced by ischemia preconditioning and postconditioning. However, it also impairs insulin signaling via its E3 ligase acti
Autor:
Fengxiang, Lv, Yingfan, Wang, Dan, Shan, Sile, Guo, Gengjia, Chen, Li, Jin, Wen, Zheng, Han, Feng, Xiaohu, Zeng, Shuo, Zhang, Yan, Zhang, Xinli, Hu, Rui-Ping, Xiao
Publikováno v:
Circulation research. 131(12)
As an integral component of cell membrane repair machinery, MG53 (mitsugumin 53) is important for cardioprotection induced by ischemia preconditioning and postconditioning. However, it also impairs insulin signaling via its E3 ligase activity-mediate
Autor:
Xinli Hu, Dan Shan, Anthony Yiu-Ho Woo, Rui-Ping Xiao, Irving W. Wainer, Ying Song, Chanjuan Xu, Yulong Li, Huan Wang, Jianfeng Liu, Yan Zhang
Publikováno v:
Circulation Research. 128:262-277
Rationale: The β 2 -adrenoceptor (β 2 -AR), a prototypical GPCR (G protein-coupled receptor), couples to both G s and G i proteins. Stimulation of the β 2 -AR is beneficial to humans and animals with heart failure presumably because it activates t
Autor:
Yuan Yao, Fan Li, Mao Zhang, Li Jin, Peng Xie, Dairu Liu, Junxia Zhang, Xinli Hu, Fengxiang Lv, Haibao Shang, Wen Zheng, Xueting Sun, Jiaxin Duanmu, Fujian Wu, Feng Lan, Rui-Ping Xiao, Yan Zhang
Publikováno v:
Circ Res
Background: CaMKII (Ca 2+ /calmodulin-dependent kinase II) plays a central role in cardiac ischemia/reperfusion (I/R) injury—an important therapeutic target for ischemic heart disease. In the heart, CaMKII-δ is the predominant isoform and further
Autor:
Xiao-Xiao Liu, Xin Xing, Shi-Qiang Wang, Rui-Ping Xiao, Yu-Pu Wang, Hua-Qian Yang, Li-Peng Wang, Lin-Lin Li, Si-Yu Zhu, Xue-Xin Fan, Tingting Hou, Yun-Yun Gong, Xiao-Ting Wang, Yan Zhang, Guang-Shen Ji
Publikováno v:
Circulation Research. 124:1350-1359
Rationale: βARs (β-adrenergic receptors) are prototypical GPCRs (G protein–coupled receptors) that play a pivotal role in sympathetic regulation. In heart cells, β 1 AR signaling mediates a global response, including both l -type Ca 2+ channels
Autor:
Ying, Song, Chanjuan, Xu, Jianfeng, Liu, Yulong, Li, Huan, Wang, Dan, Shan, Irving W, Wainer, Xinli, Hu, Yan, Zhang, Anthony Yiu-Ho, Woo, Rui-Ping, Xiao
Publikováno v:
Circulation research. 128(2)
The βHere, we aim to investigate the potential cardioprotective effect of βUsing pharmacological, genetic and biophysical protein-protein interaction approaches, we studied the cardioprotective effect of the βThese data demonstrate that the β
Autor:
Hua-Qian, Yang, Li-Peng, Wang, Yun-Yun, Gong, Xue-Xin, Fan, Si-Yu, Zhu, Xiao-Ting, Wang, Yu-Pu, Wang, Lin-Lin, Li, Xin, Xing, Xiao-Xiao, Liu, Guang-Shen, Ji, TingTing, Hou, Yan, Zhang, Rui-Ping, Xiao, Shi-Qiang, Wang
Publikováno v:
Circulation research. 124(9)
βARs (β-adrenergic receptors) are prototypical GPCRs (G protein-coupled receptors) that play a pivotal role in sympathetic regulation. In heart cells, βTo investigate the signaling relationship between βUsing whole-cell patch-clamp analyses combi
Publikováno v:
Circulation Research. 106:102-110
Rationale : Ca 2+ /calmodulin-dependent protein kinase (CaMK)II is a multifunctional kinase involved in vital cellular processes such as Ca 2+ handling and cell fate regulation. In mammalian heart, 2 primary CaMKII isoforms, δB and δC, localize in
Publikováno v:
Circulation Research. 101:1113-1122
Previous studies have shown that mitofusin 2 ( Mfn-2 ) (or hyperplasia suppressor gene [ HSG ]) inhibits vascular smooth muscle cell (VSMC) proliferation. Here, we demonstrate that Mfn-2 is a primary determinant of VSMC apoptosis. First, oxidative st
Autor:
Weizhong Zhu, Dongmei Yang, Heping Cheng, Rui-Ping Xiao, S.R. Wayne Chen, Edward G. Lakatta, Didier X.P. Brochet, Bailong Xiao
Publikováno v:
Circulation Research. 100:399-407
The multifunctional Ca 2+ /calmodulin-dependent protein kinase II δ C (CaMKIIδ C ) is found in the macromolecular complex of type 2 ryanodine receptor (RyR2) Ca 2+ release channels in the heart. However, the functional role of CaMKII-dependent phos