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Autor:
Mark W. Chapleau, Fayyaz S. Sutterwala, David K. Meyerholz, Zuhair K. Ballas, Jason A Ratcliff, Sailesh C. Harwani, Francois M. Abboud
Publikováno v:
Circulation Research. 119:1101-1115
Rationale: Renal inflammation contributes to the pathophysiology of hypertension. CD161a + immune cells are dominant in the (SHR) spontaneously hypertensive rat and expand in response to nicotinic cholinergic activation. Objective: We aimed to phenot
Publikováno v:
Circulation research. 119(3)
Drs Zhou and Zhou1 write a challenging letter that aims to turn concepts of sympathetic nerve biology and norepinephrine plasma kinetics upside down. Their letter claims that there is a previously unsuspected primary importance for platelets in norep
Autor:
Shi-Sheng Zhou, Yiming Zhou
Publikováno v:
Circulation Research. 119
Increased renal norepinephrine spillover, observed by using isotope-dilution method, is thought to indicate renal sympathetic hyperactivity and to play a crucial role in hypertension. However, SYMPLICITY HTN-3 (Renal Denervation in Patients With Unco
Autor:
Ian A. White
Publikováno v:
Circulation research. 118(8)
The pathophysiology of heart failure (HF) has long been linked to a neurohormonal imbalance because of excessive compensatory activation of the sympathetic nervous system (SNS).1–3 As HF develops, cardiac function is progressively lost prompting an
Autor:
Zhenheng Guo, Venkateswaran Subramanian, Jessica J. Moorleghen, Coleen A. McNamara, A. Phillip Owens, Lisa A. Cassis, Alan Daugherty
Publikováno v:
Circulation Research. 106:611-619
Rationale : Angiotensin II (Ang II) has diverse effects on smooth muscle cells (SMCs). The diversity of effects may relate to the regional location of this cell type. Objective : The aim of this study was to define whether Ang II exerted divergent ef
Autor:
Kazuto Yamazaki, Keiichi Fukuda, Masaki Ieda, Makoto Tsunoda, Kenji Yoshimi, Satoshi Ogawa, Kensuke Kimura, Hideki Mochizuki, Takashi Yagi, Shin Ichi Ninomiya, Hideaki Kanazawa, Hiroyuki Kurosawa
Publikováno v:
Circulation Research. 100:1755-1764
Neuronal function and innervation density is regulated by target organ-derived neurotrophic factors. Although cardiac hypertrophy drastically alternates the expression of various growth factors such as endothelin-1, angiotensin II, and leukemia inhib
Autor:
Fabio A. Recchia, Mauro Giacca
Publikováno v:
Circulation Research. 97:847-849
See related article, pages 928–936 Heart failure is characterized by sympathetic nervous system activation with consequent increase in cardiac and systemic norepinephrine (NE) release. Sympathetic hyperactivity preferentially targets the heart duri
Autor:
Kathleen H. Berecek, Shereeni J. Veerasingham, Masanobu Yamazato, Mohan K. Raizada, J. Michael Wyss
Publikováno v:
Circulation Research. 96:277-279
Existing evidence led us to hypothesize that increases in p85α, a regulatory subunit of PI3-kinase, in presympathetic brain areas contribute to hypertension. PI3-kinase p85α, p110α, and p110δ mRNA was 1.5- to 2-fold higher in the paraventricular
Publikováno v:
Circulation Research. 75:347-356
Pulmonary hypertension in congestive heart failure causes medial hypertrophy in pulmonary vessels and thickening of the endothelial basement membrane. In this study, the functional consequences of such pulmonary vascular adaptations were evaluated. H
Publikováno v:
Circulation Research. 72:816-826
We determined whether a 3-minute period of intense cardiac sympathetic stimulation, which is known to release neuropeptide Y (NPY), elicits a sustained poststimulatory coronary vasoconstriction in anesthetized dogs that had received propranolol. We a