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Autor:
Takashi Iwase, Kazue Ishikawa, Sumiko Yoshida, Yuka Sumitomo, Toshio Matsumoto, Yasumasa Ikeda, Ken-ichi Aihara, Hiroyuki Azuma, Takayuki Ise, Masashi Akaike, Shusuke Yagi
Publikováno v:
Circulation Research. 102:68-76
Angiotensin II (Ang II) plays a pivotal role in cardiovascular remodeling leading to hypertension, myocardial infarction, and stroke. Pitavastatin, an HMG-CoA reductase inihibitor, is known to have pleiotropic actions against the development of cardi
Autor:
James J. M. Greer, Ling Tao, Christopher G. Kevil, Hunter C. Champion, Will Langston, David J. Lefer, Mark R. Duranski, John W. Elrod, Tammy R. Dugas
Publikováno v:
Circulation Research. 99:78-85
Previous studies indicate that endothelial nitric oxide synthase (eNOS) function is impaired in diabetes as a result of increased vascular generation of reactive oxygen species. We hypothesized that eNOS gene therapy would augment NO· bioavailabilit
Autor:
Cuihua Zhang, Souad Belmadani, Andrea Picchi, William M. Chilian, Barry J. Potter, Xue Gao, Marta Focardi
Publikováno v:
Circulation Research. 99:69-77
Inflammation is a condition that underscores many cardiovascular pathologies including endothelial dysfunction, but no link is yet established between the vascular pathology of the metabolic syndrome with a particular inflammatory cytokine. We hypoth
Autor:
Hideto Kojima, Hiroshi Maegawa, Atsunori Kashiwagi, Noboru Toda, Yoshihiko Nishio, Tomio Okamura, Yuichi Yoshida, Masahiro Masada, Ryuichi Kikkawa, Kazuya Shinozaki
Publikováno v:
Circulation Research. 87:566-573
Abstract —We have reported that a deficiency of tetrahydrobiopterin (BH 4 ), an active cofactor of endothelial NO synthase (eNOS), contributes to the endothelial dysfunction through reduced eNOS activity and increased superoxide anion (O 2 − ) ge
Publikováno v:
Circulation Research. 83:431-440
Abstract —Myocytes overlying a zone of infarction form the primary substrate for serious reentrant ventricular arrhythmias. In vitro and in vivo studies suggest that antiarrhythmic agents affect Na + channels of cells from the epicardial border zon
Autor:
David R. Murray, Gregory L. Freeman
Publikováno v:
Circulation Research. 78:154-160
Abstract Tumor necrosis factor-α (TNF-α) likely plays a role in the pathophysiology of myocardial depression observed in septic shock. To evaluate the hemodynamic effects of TNF-α in vivo while eliminating the influence of altered sympathetic tone
Autor:
Xian Liang Tang, Selim Sekili, Marcel E. Zughaib, Roberto Bolli, Mohamed O. Jeroudi, Jian Zhong Sun
Publikováno v:
Circulation Research. 76:82-94
Abstract Recent evidence suggests a cardioprotective effect of adenosine in myocardial ischemia and reperfusion. The present study was undertaken to determine (1) whether adenosine attenuates myocardial stunning, (2) if so, whether the beneficial eff
Publikováno v:
Circulation Research. 74:937-944
We studied the receptor-effector coupling mechanism responsible for alpha 1-adrenergic receptor-induced increases in abnormal automaticity (AA) occurring at low membrane potentials in "ischemic" Purkinje fibers, superfused with Tyrode's solution cont
Autor:
Zhenhai Yao, G. J. Gross
Publikováno v:
Circulation Research. 73:1193-1201
The aims of the current study were to examine the efficacy of acetylcholine (ACh) to mimic ischemic preconditioning in dogs and to determine the role of nitric oxide (NO), muscarinic receptors, and ATP-sensitive K+ (KATP) channels in mediating its ef
Publikováno v:
Circulation Research. 72:1004-1010
We examined the natural course of endothelium-dependent and -independent responses in reversed autogenous vein grafts during regeneration and tissue repair processes after vein grafting in dogs. Vein grafts implanted in the canine femoral artery were