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Autor:
Chinedu Igwe, Marc S. Penn
Publikováno v:
Circulation research. 119(12)
Although no doubt an oversimplification, in many respects, a significant portion of cardiovascular trials in the late 1990s and early 2000s demonstrated that whether we do not clot we do not die as long as we do not bleed to death. These trials were
Autor:
Walter J. Koch, Xiying Shang, Yong Hong Lei, J. Kurt Chuprun, Erhe Gao, Lin Zuo, Matthieu Boucher, Z. Maggie Huang, Qian Fan, Xin L. Ma
Publikováno v:
Circulation Research. 107:1445-1453
Rationale: Coronary artery ligation to induce myocardial infarction (MI) in mice is typically performed by an invasive and time-consuming approach that requires ventilation and chest opening (classic method), often resulting in extensive tissue damag
Autor:
Andreas Skyschally, Rainer Schulz, Petra Gres, Simone Hoffmann, Raimund Erbel, Michael Haude, Gerd Heusch
Publikováno v:
Circulation Research. 100:140-146
In patients with unstable angina, plaque rupture and coronary microembolization (ME) can precede complete coronary artery occlusion and impending infarction. ME-induced microinfarcts initiate an inflammatory reaction with increased tumor necrosis fac
Autor:
Christophe Adrie, Kenneth D. Bloch, Howard J. Jacob, Warren M. Zapol, Joon S. Lee, Jesse D. Roberts
Publikováno v:
Circulation Research. 78:337-342
Abstract Systemic and local intravascular NO administration inhibits neointimal formation after vascular injury in animal models. NO appears to attenuate smooth muscle proliferation both directly and indirectly by preventing the release of growth fac
Autor:
Xian Liang Tang, Selim Sekili, Marcel E. Zughaib, Roberto Bolli, Mohamed O. Jeroudi, Jian Zhong Sun
Publikováno v:
Circulation Research. 76:82-94
Abstract Recent evidence suggests a cardioprotective effect of adenosine in myocardial ischemia and reperfusion. The present study was undertaken to determine (1) whether adenosine attenuates myocardial stunning, (2) if so, whether the beneficial eff
Publikováno v:
Circulation Research. 72:1091-1102
Recombinant desulfatohirudin (HI), a potent and specific thrombin inhibitor, was compared with heparin (HE) as an adjunct to streptokinase thrombolysis. In pentobarbital-anesthetized dogs, an occlusive thrombus (whole blood+thrombin) was introduced i
Publikováno v:
Circulation Research. 72:440-454
We determined the influences of breathing-induced changes in intrathoracic and intravascular pressures, central respiratory drive, and pulmonary vagal feedback on the within-breath variation in skeletal muscle sympathetic nerve activity (MSNA) in hum
Publikováno v:
Circulation Research. 70:1152-1160
Antistasin is a 119-amino acid protein initially isolated from salivary glands of the Mexican leech, Haementeria officinalis, that exhibits potent anticoagulant properties resulting from selective inhibition of blood coagulation factor Xa. The compar
Autor:
Warren Smith, Xiaohong Zhou, Stephen B. Knisley, D. L. Rollins, Patrick D. Wolf, Raymond E. Ideker
Publikováno v:
Circulation Research. 68:1761-1767
Recent studies suggest that 1) electrically induced fibrillation and defibrillation involve prolongation of refractoriness by the shock in addition to stimulation and 2) biphasic waveforms are more efficient for defibrillation than are comparable mon
Publikováno v:
Circulation Research. 68:1652-1659
A number of scavengers of reactive oxygen metabolites reduce myocardial injury when given before ischemia and reperfusion, but few, if any, have proven to be effective when given near the onset of reperfusion. This is particularly true when infarct s