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Autor:
Christophe Adrie, Kenneth D. Bloch, Howard J. Jacob, Warren M. Zapol, Joon S. Lee, Jesse D. Roberts
Publikováno v:
Circulation Research. 78:337-342
Abstract Systemic and local intravascular NO administration inhibits neointimal formation after vascular injury in animal models. NO appears to attenuate smooth muscle proliferation both directly and indirectly by preventing the release of growth fac
Autor:
Robert E. Michler, Nepal C. Chowdhury, David J. Pinsky, Hui Liao, Mehmet C. Oz, Yoshifumi Naka, Dilip K. Roy
Publikováno v:
Circulation Research. 76:900-906
Abstract Nitric oxide (NO) produced within the lungs maintains pulmonary vascular homeostatic properties, modulating leukocyte traffic, platelet aggregation, and vasomotor tone. Because reactive oxygen intermediates generated during reperfusion react
Autor:
Warren Smith, Xiaohong Zhou, Stephen B. Knisley, D. L. Rollins, Patrick D. Wolf, Raymond E. Ideker
Publikováno v:
Circulation Research. 68:1761-1767
Recent studies suggest that 1) electrically induced fibrillation and defibrillation involve prolongation of refractoriness by the shock in addition to stimulation and 2) biphasic waveforms are more efficient for defibrillation than are comparable mon
Publikováno v:
Circulation Research. 68:1652-1659
A number of scavengers of reactive oxygen metabolites reduce myocardial injury when given before ischemia and reperfusion, but few, if any, have proven to be effective when given near the onset of reperfusion. This is particularly true when infarct s
Publikováno v:
Circulation Research. 68:438-449
The mechanism of biphasic waveform defibrillation threshold reduction is unknown. We tested the hypothesis that, during refractory period stimulation, sarcolemmal hyperpolarization by the first pulse of biphasic waveforms facilitates excitation chann
Publikováno v:
Circulation research. 77(2)
Abstract Recent studies have suggested that mild redox alterations can regulate cell function. Therefore, we tested the hypothesis that alteration in the thiol redox state might be responsible for the cardioprotective effects conferred by ischemic pr
Autor:
Michiko Momohara, Tsutomu Imaizumi, Tatsuya Tagawa, Hiroyuki Masaki, Akira Takeshita, Shigehiko Tokunaga, Seiki Harada
Publikováno v:
Circulation research. 72(3)
It has been shown that nitric oxide (NO) is synthesized in the central nervous system as well as in vascular endothelial cells. However, the physiological role of NO in cardiovascular regulation by the central nervous system remains unclear. This obj
Publikováno v:
Circulation research. 69(2)
This investigation tested in rats whether MK-801, an N-methyl-D-aspartate receptor antagonist, would improve the balance of oxygen supply and consumption in the focal ischemic area of the brain induced by occlusion of the middle cerebral artery. Fift
Publikováno v:
Circulation Research. 38:566-571
Cardiac prostaglandin release was studied in closed-chest dogs during acute coronary occlusion. Aortic and coronary sinus blood was obtained before, and at intervals after, balloon occlusion of the left anterior descending artery in seven dogs. Sampl
Autor:
Atsuhiro Otsuka, Hiroshi Mikami, Ogihara T, T. Tsunetoshi, Katsuhiko Kohara, Katsutoshi Katahira, Yuichi Kumahara
Publikováno v:
Circulation Research. 65:1467-1474
Dextran in lactated Ringer's solution (20 ml/kg) was infused for 1 hour into anesthetized dogs with sinoaortic denervation and vagotomy (deafferentation; n = 10) and dogs treated with hexamethonium (de-efferentation; n = 13) to compare with our previ