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of 415
pro vyhledávání: ''
Autor:
Uwe J. F. Tietge, Stephan J. L. Bakker, Robin P. F. Dullaart, Eke G. Gruppen, Josephine L. C. Anderson, Congzhuo Jia, Yu Lei
Publikováno v:
Circulation, 143(20), 1935-1945. LIPPINCOTT WILLIAMS & WILKINS
Circulation
Circulation
Background: The role of high-density lipoprotein (HDL) function in cardiovascular disease represents an important emerging concept. The present study investigated whether HDL anti-inflammatory capacity is prospectively associated with first cardiovas
Autor:
Fan Xiaohang, Qiang Hao, Qinghua Hu, Shengquan Luo, Rui Xiao, Ting Zhang, Matthieu Ruiz, Xianqin Zeng, Ping Yuan, Tian Feng, Jin-Ming Liu, Jian-Guo He, Liping Zhu, Fangbo Liu, Zeshuai Chen, Jocelyn Dupuis, Mengxiang Sun
Publikováno v:
Circulation. 143:1775-1792
Background: The mevalonate pathway generates endogenous cholesterol and intermediates including geranylgeranyl pyrophosphate (GGPP). By reducing GGPP production, statins exert pleiotropic or cholesterol-independent effects. The potential regulation o
Publikováno v:
Circulation
Autor:
Kavisha Singh, Eke G. Gruppen, Thomas Sperry, Salim S. Virani, Amit Khera, Christie M. Ballantyne, Alvin Chandra, Parag H. Joshi, Robin P. F. Dullaart, Margery A. Connelly, Anand Rohatgi, James D. Otvos, Colby Ayers
Publikováno v:
Circulation
Circulation, 142(7), 657-669. LIPPINCOTT WILLIAMS & WILKINS
Circulation, 142(7), 657-669. LIPPINCOTT WILLIAMS & WILKINS
Supplemental Digital Content is available in the text.
Background: High-density lipoprotein (HDL) cholesterol concentration (HDL-C) is an established atheroprotective marker, in particular for coronary artery disease; however, HDL particle conce
Background: High-density lipoprotein (HDL) cholesterol concentration (HDL-C) is an established atheroprotective marker, in particular for coronary artery disease; however, HDL particle conce
Autor:
José V. Sorlí, Mònica Bulló, Lluis Serra-Majem, María Trinidad Soria-Florido, Miguel Ruiz-Canela, Enrique Gómez-Gracia, Fernando Arós, Montserrat Fitó, Miquel Fiol, Camille Lassale, Miguel Ángel Martínez-González, Dolores Corella, Emilio Ros, Ángel M. Alonso-Gómez, Olga Castañer, Roberto Elosua, Álvaro Hernáez, Xavier Pintó, Jordi Salas-Salvadó, José Lapetra, Ramon Estruch
Publikováno v:
Circulation. 141:444-453
Background: Studies have failed to establish a clear link between high-density lipoprotein (HDL) cholesterol and cardiovascular disease, leading to the hypothesis that the atheroprotective role of HDL lies in its biological activity rather than in it
Autor:
Seung-Hwan Lee, Yong-Moon Park, Kyungdo Han, Gunseog Kang, Hyuk-Sang Kwon, Kun-Ho Yoon, Mee Kyoung Kim
Publikováno v:
Circulation. 138:2627-2637
Background: Variability in metabolic parameters, such as fasting blood glucose and cholesterol concentrations, blood pressure, and body weight can affect health outcomes. We investigated whether variability in these metabolic parameters has additive
Autor:
Kausik K. Ray, John J.P. Kastelein, Peter L.J. Wijngaard, Lawrence A. Leiter, Robert M. Stoekenbroek, Ulf Landmesser, R. Scott Wright, David Kallend
Publikováno v:
Circulation. 138:1304-1316
Background: The ORION-1 trial (Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol [LDL-C]) demonstrated that inclisiran, an siRNA therapeutic that targets protease proprotein convertase subtilisin/kexin type 9
Autor:
Roger S. Blumenthal, Renato Quispe, Erin D. Michos, Seamus P. Whelton, Peter P. Toth, Mohamed B. Elshazly, Steven R. Jones, Vasanth Sathiyakumar, Seth S. Martin, Maciej Banach, Jihwan Park
Publikováno v:
Circulation. 138:244-254
Background: Selected dyslipidemia guidelines recommend non-high-density lipoprotein-cholesterol (non-HDL-C) and apolipoprotein B (apoB) as secondary targets to the primary target of low-density lipoprotein-cholesterol (LDL-C). After considering 2 LDL
Autor:
David D. Waters, Philip J. Barter, S. Matthijs Boekholdt, Antonio J. Vallejo-Vaz, John J.P. Kastelein, Rana Fayyad, Shari Melamed, G. Kees Hovingh, Kausik K. Ray
Publikováno v:
Circulation, vol 138, iss 8
Circulation, 138(8), 770-781. Lippincott Williams and Wilkins
Circulation, 138(8), 770-781. Lippincott Williams and Wilkins
Background: Mendelian randomization data suggest that the genetic determinants of lifetime higher triglyceride-rich lipoprotein-cholesterol (TRL-C) are causally related to cardiovascular disease and therefore a potential therapeutic target. The relev
Autor:
Dominique Larrey, Daniel J. Rader, Pamela Foulds, Claudia Stefanutti, Emma A. Meagher, LeAnne T. Bloedon, Daniel Gaudet, Dirk J. Blom, Maurizio Averna, Cesare R. Sirtori, Giovanni Battista Vigna, Robert A. Hegele, Marina Cuchel, Hendrik Du Toit Theron, Prediman K. Shah
Publikováno v:
Circulation. 136:332-335
Homozygous familial hypercholesterolemia is a genetic disorder characterized by low-density lipoprotein (LDL)-receptor dysfunction, markedly elevated levels of LDL-cholesterol (LDL-C) and premature atherosclerosis. Patients are often poorly responsiv