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Publikováno v:
Chem Res Toxicol
Methimazole (MMI) is a widely used antithyroid drug, but it can cause hepatotoxicity by unknown mechanisms. Previous studies showed that the hepatic metabolism of MMI produces N-methylthiourea, leading to liver damage. However, the specific enzyme re
Publikováno v:
Chemical Research in Toxicology. 34:2135-2144
Atomoxetine (ATX) is a neurological drug widely used for the treatment of attention deficit-hyperactivity disorder. Liver injury has been documented in patients administered ATX. The mechanism of ATX's toxic action is less clear. This study is aimed
Autor:
Ying Zhong, Yang Li, Haoni Yan, Dapang Rao, Cheng Zou, Zina Wen, Xiaoheng Li, Ren-Shan Ge, Changchang Li, Yiyan Wang, Peipei Pan, Yingfen Ying, Huitao Li, Song Zhang
Publikováno v:
Chemical Research in Toxicology. 34:1542-1555
Perfluorotridecanoic acid (PFTrDA) is a long-chain (C13) perfluoroalkyl carboxylic acid. Here, we report the influence of PFTrDA exposure on the maturation of rat Leydig cells in late puberty in vivo. Male Sprague-Dawley rats were administered PFTrDA
Publikováno v:
Chemical Research in Toxicology. 34:1578-1587
Toxic effects induced upon exposure to low-dose bisphenol A (BPA) or bisphenol S (BPS) remains controversial. In this study, metabolomics was used to examine the metabolomic perturbation arising from 28 days of exposure to BPA or BPS at 50 μg/kg bw/
Publikováno v:
Chemical Research in Toxicology. 34:1348-1354
Linezolid, the principal oxazolidinone antibiotic for therapy of Gram-positive infections, is limited by its myelosuppression and monoamine oxidase (MAO) inhibition, with the latter manifested as serotonergic neurotoxicity. The oral oxazolidinone con
Publikováno v:
Chemical Research in Toxicology. 34:1612-1618
Labetalol hydrochloride (LHCl), an α- and β-adrenoreceptor blocker, is widely used for the treatment of hypertension as well as angina pectoris. Previous reports have demonstrated the adverse events during clinical application of LHCl, such as live
Publikováno v:
Chemical Research in Toxicology. 34:1286-1295
Glutamate is the major excitatory neurotransmitter in the brain and is involved in many brain functions. In this study, we investigated whether typhaneoside, a flavonoid from Typhae angustifolia pollen, affects endogenous glutamate release from rat c
Autor:
Guodong Cao, Lin Zhu, Jialing Huang, Zongwei Cai, Peisi Xie, Yuanyuan Song, Wei Huang, Xiangfeng Chen
Publikováno v:
Chemical Research in Toxicology. 34:1319-1328
Triclosan (TCS) is a ubiquitous antimicrobial used in many daily consumer products. It has been reported to induce endocrine disrupting effects at low doses in mammals, disturbing sex hormone function and thyroid function. The hypothalamus plays a cr
Publikováno v:
Chemical Research in Toxicology. 34:857-864
Sodium hydrosulfide (NaHS), as an exogenous hydrogen sulfide (H2S) donor, has been used in various pathological models. NaHS is usually considered to be primarily protective, however, the toxic effect of NaHS has not been well elucidated. The aim of
Autor:
Henry F. VanBrocklin, John M. Gerdes, Tony Huynh, Charles M. Thompson, Thomas R. Hayes, Kurt R. Zinn, Chih-Kai Chao, Joseph E. Blecha
Publikováno v:
Chem Res Toxicol
[Image: see text] Organophosphorus esters (OPs) were originally developed as pesticides but were repurposed as easily manufactured, inexpensive, and highly toxic chemical warfare agents. Acute OP toxicity is primarily due to inhibition of acetylcholi