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Autor:
Ying Zhong, Yang Li, Haoni Yan, Dapang Rao, Cheng Zou, Zina Wen, Xiaoheng Li, Ren-Shan Ge, Changchang Li, Yiyan Wang, Peipei Pan, Yingfen Ying, Huitao Li, Song Zhang
Publikováno v:
Chemical Research in Toxicology. 34:1542-1555
Perfluorotridecanoic acid (PFTrDA) is a long-chain (C13) perfluoroalkyl carboxylic acid. Here, we report the influence of PFTrDA exposure on the maturation of rat Leydig cells in late puberty in vivo. Male Sprague-Dawley rats were administered PFTrDA
Publikováno v:
Chemical Research in Toxicology. 34:1578-1587
Toxic effects induced upon exposure to low-dose bisphenol A (BPA) or bisphenol S (BPS) remains controversial. In this study, metabolomics was used to examine the metabolomic perturbation arising from 28 days of exposure to BPA or BPS at 50 μg/kg bw/
Publikováno v:
Chemical Research in Toxicology. 34:1348-1354
Linezolid, the principal oxazolidinone antibiotic for therapy of Gram-positive infections, is limited by its myelosuppression and monoamine oxidase (MAO) inhibition, with the latter manifested as serotonergic neurotoxicity. The oral oxazolidinone con
Publikováno v:
Chemical Research in Toxicology. 34:1612-1618
Labetalol hydrochloride (LHCl), an α- and β-adrenoreceptor blocker, is widely used for the treatment of hypertension as well as angina pectoris. Previous reports have demonstrated the adverse events during clinical application of LHCl, such as live
Publikováno v:
Chemical Research in Toxicology. 34:1286-1295
Glutamate is the major excitatory neurotransmitter in the brain and is involved in many brain functions. In this study, we investigated whether typhaneoside, a flavonoid from Typhae angustifolia pollen, affects endogenous glutamate release from rat c
Publikováno v:
Chemical Research in Toxicology. 34:857-864
Sodium hydrosulfide (NaHS), as an exogenous hydrogen sulfide (H2S) donor, has been used in various pathological models. NaHS is usually considered to be primarily protective, however, the toxic effect of NaHS has not been well elucidated. The aim of
Autor:
Henry F. VanBrocklin, John M. Gerdes, Tony Huynh, Charles M. Thompson, Thomas R. Hayes, Kurt R. Zinn, Chih-Kai Chao, Joseph E. Blecha
Publikováno v:
Chem Res Toxicol
[Image: see text] Organophosphorus esters (OPs) were originally developed as pesticides but were repurposed as easily manufactured, inexpensive, and highly toxic chemical warfare agents. Acute OP toxicity is primarily due to inhibition of acetylcholi
Autor:
Pramod Upadhyaya, Jiehong Guo, Stephen S. Hecht, Robert J. Turesky, Haoqing Chen, Yingchun Zhao
Publikováno v:
Chem Res Toxicol
Metabolic activation of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N’-nitrosonornicotine (NNN) results in formation of reactive electrophiles that modify DNA to produce a variety of produ
Autor:
Xiucai Guo, Jiang Zheng, Qingmei Li, Ying Peng, Wei Li, Qian Zou, Jiaxing Zhao, Ruixue Tian, Zixin Yang
Publikováno v:
Chemical Research in Toxicology. 33:2351-2360
2,4-Dichlorophenol (2,4-DCP), an environmental pollutant, was reported to cause hepatotoxicity. The biochemical mechanisms of 2,4-DCP induced liver injury remain unknown. The present study showed that 2,4-DCP is chemically reactive and spontaneously
Autor:
Michael J Bauer, George R. Douglas, Patricia B. Upton, Dale M. Walker, Vernon E. Walker, Timothy R. Fennell, James A. Swenberg
Publikováno v:
Chemical Research in Toxicology. 33:1609-1622
Acrylonitrile (ACN), which is a widely used industrial chemical, induces cancers in multiple organs/tissues of rats by unresolved mechanisms. For this report, evidence for ACN-induced direct/indirect DNA damage and mutagenesis was investigated by ass