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Publikováno v:
Chem Res Toxicol
Methimazole (MMI) is a widely used antithyroid drug, but it can cause hepatotoxicity by unknown mechanisms. Previous studies showed that the hepatic metabolism of MMI produces N-methylthiourea, leading to liver damage. However, the specific enzyme re
Publikováno v:
Chemical Research in Toxicology. 34:2135-2144
Atomoxetine (ATX) is a neurological drug widely used for the treatment of attention deficit-hyperactivity disorder. Liver injury has been documented in patients administered ATX. The mechanism of ATX's toxic action is less clear. This study is aimed
Publikováno v:
Chemical Research in Toxicology. 34:1348-1354
Linezolid, the principal oxazolidinone antibiotic for therapy of Gram-positive infections, is limited by its myelosuppression and monoamine oxidase (MAO) inhibition, with the latter manifested as serotonergic neurotoxicity. The oral oxazolidinone con
Publikováno v:
Chemical Research in Toxicology. 34:1612-1618
Labetalol hydrochloride (LHCl), an α- and β-adrenoreceptor blocker, is widely used for the treatment of hypertension as well as angina pectoris. Previous reports have demonstrated the adverse events during clinical application of LHCl, such as live
Autor:
Guodong Cao, Lin Zhu, Jialing Huang, Zongwei Cai, Peisi Xie, Yuanyuan Song, Wei Huang, Xiangfeng Chen
Publikováno v:
Chemical Research in Toxicology. 34:1319-1328
Triclosan (TCS) is a ubiquitous antimicrobial used in many daily consumer products. It has been reported to induce endocrine disrupting effects at low doses in mammals, disturbing sex hormone function and thyroid function. The hypothalamus plays a cr
Publikováno v:
Chemical Research in Toxicology. 34:857-864
Sodium hydrosulfide (NaHS), as an exogenous hydrogen sulfide (H2S) donor, has been used in various pathological models. NaHS is usually considered to be primarily protective, however, the toxic effect of NaHS has not been well elucidated. The aim of
Autor:
Makiko Shimizu, Hiroshi Yamazaki, Shotaro Uehara, Tomonori Miura, Ayane Nakano, Yusuke Kamiya, Manae Yoshizawa, Mayu Yanagi, Hiroshi Suemizu, Norie Murayama
Publikováno v:
Chemical Research in Toxicology. 33:3048-3053
Bromobenzene is an industrial solvent that elicits toxicity predominantly in the liver. In this study, the hepatic concentrations of bromobenzene and its related compounds 1,2-dibromobenzene and 1,4-dibromobenzene in humanized-liver mice were predict
Publikováno v:
Chemical Research in Toxicology. 33:2208-2217
Nomilin is a furan-containing triterpenoid isolated from the medicinal plants of citrus. The aim of this study was to investigate the in vitro and in vivo bioactivation of nomilin and the role in nomilin-induced hepatotoxicity. Microsomal incubations
Autor:
Shuwen Liu, Wenyu Cao, Weizhong Chen, Yilin Huang, Zheng Cai, Zhikun Zhan, Yong Cao, Zhihao Mao, Lan Tang, Fahong Dai, Yulian Chen, Tao Zhang, Lili Wu
Publikováno v:
Chemical Research in Toxicology. 33:1798-1808
Emodin is the main toxic component in Chinese medicinal herbs such as rhubarb. Our previous studies demonstrated that genetic polymorphisms of UDP-glucuronosyltransferase 2B7 (UGT2B7) had an effect on the glucuronidation and detoxification of emodin.
Publikováno v:
Chemical Research in Toxicology. 33:940-947
Columbin, a furanoid compound, is the major bioactive ingredient of Tinospora sagittata (Oliv.) Gagnep, a traditional Chinese medicine that has been reported to cause liver injury in the clinic. The aim of this study was to investigate the hepatotoxi