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Publikováno v:
Chemical Research in Toxicology. 29:2145-2152
Benzbromarone (BBR) is a therapeutically useful uricosuric agent but can also cause acute liver injury. The hepatotoxicity of BBR is suggested to be associated with its metabolic activation. Our recent metabolic study demonstrated that BBR was metabo
Autor:
Donald F. Stec, Markus Voehler, Dapo Akingbade, Charles G. Knutson, Brenda C. Crews, Lawrence J. Marnett
Publikováno v:
Chemical Research in Toxicology. 20:550-557
Oxidative damage is considered a major contributing factor to genetic diseases including cancer. Our laboratory is evaluating endogenously formed DNA adducts as genomic biomarkers of oxidative injury. Recent efforts have focused on investigating the
Publikováno v:
Chemical Research in Toxicology. 19:710-718
A sensitive and selective capillary liquid chromatography nanoelectrospray isotope dilution mass spectrometric method was developed to identify and quantify the endogenous cyclic DNA adducts derived from trans-4-hydroxy-2-nonenal with 2'-deoxyguanosi
Publikováno v:
Chemical Research in Toxicology. 16:838-846
Botanical dietary supplements containing Cimicifuga racemosa (Actaea racemosa; black cohosh) are used commonly by women to assuage menopausal symptoms including hot flashes and sleep disorders. Despite the popularity of such supplements, little is kn
Autor:
Christopher Quirk, Julian L. Griffin, Wendy M. Purcell, Jeremy K. Nicholson, Jinsheng Xu, Elaine Holmes, Mary E. Bollard
Publikováno v:
Chemical Research in Toxicology. 15:1351-1359
We report here the combined application of (1)H magic angle spinning (MAS) and high-resolution NMR spectroscopy and pattern recognition methods to study the effects of a model toxin (D-galactosamine) in liver spheroid cultures. (1)H NMR spectra of me
Autor:
Robert J Espina, John Shockcor, Michael J. Orwat, Shiang-Yuan Chen, Liang-Shang Gan, Shimoga R. Prakash, Abdul E Mutlib, Donald J. P. Pinto
Publikováno v:
Chemical Research in Toxicology. 15:48-62
The in vitro and in vivo disposition of DPC 423 was investigated in mice, rats, dogs and humans and the metabolites characterized by LC/MS, LC/NMR and high field-NMR. The rodents produced several metabolites that included an aldehyde (M1), a carboxyl
Publikováno v:
Chemical Research in Toxicology. 13:1349-1359
A series of arylalkyl isothiocyanates were evaluated for their ability to inactivate purified cytochrome P450 2B1 in a reconstituted system. Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC) occur naturally in several cruciferous vege
Publikováno v:
Chemical Research in Toxicology. 12:429-436
The release and subsequent reuptake of 5-hydroxytryptamine (5-HT) and cytoplasmic superoxide (O2-*) generation have both been implicated as important factors associated with the degeneration of serotonergic neurons evoked by methamphetamine (MA) and
Publikováno v:
Chemical Research in Toxicology. 12:396-402
The recent development of several promising new thiourea-containing drugs has renewed interest in the thiourea functionality as a potential toxicophore. Most adverse reactions of thiourea-containing compounds are attributed to the thionocarbonyl moie
Publikováno v:
Chemical Research in Toxicology. 11:1508-1515
The metabolism of three mono-ortho-substituted congeners, 2,3,3',4, 4'-pentachlorobiphenyl (CB105), 2,3',4,4',5-pentachlorobiphenyl (CB118), and 2,3,3',4,4',5-hexachlorobiphenyl (CB156), was investigated with regard to the identification of hydroxy-