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Publikováno v:
Chemical Research in Toxicology. 33:2208-2217
Nomilin is a furan-containing triterpenoid isolated from the medicinal plants of citrus. The aim of this study was to investigate the in vitro and in vivo bioactivation of nomilin and the role in nomilin-induced hepatotoxicity. Microsomal incubations
Autor:
Michael J Bauer, George R. Douglas, Patricia B. Upton, Dale M. Walker, Vernon E. Walker, Timothy R. Fennell, James A. Swenberg
Publikováno v:
Chemical Research in Toxicology. 33:1609-1622
Acrylonitrile (ACN), which is a widely used industrial chemical, induces cancers in multiple organs/tissues of rats by unresolved mechanisms. For this report, evidence for ACN-induced direct/indirect DNA damage and mutagenesis was investigated by ass
Publikováno v:
Chemical Research in Toxicology. 33:594-603
Three cobalt-containing macrocyclic compounds previously shown to antagonize cyanide toxicity have been comparatively evaluated for the amelioration of sublethal azide toxicity in juvenile (7-8 weeks) Swiss-Webster mice. The lowest effective doses we
Publikováno v:
Chemical research in toxicology. 34(11)
Covalent drugs are newly developed and proved to be successful therapies in past decades. However, the pharmacokinetics (PK) and pharmacodynamic (PD) studies of covalent drugs now ignore the drug and metabolite-protein modification. The low abundance
Autor:
Anton Ribbenstedt, Jonathan W. Martin, Karim Fouad, Trevor J. Hamilton, Anthony J.F. Reardon, Jacqueline Karathra, David Kinniburgh, Amy M MacDonald, Jonathan P. Benskin
Publikováno v:
Chemical Research in Toxicology. 32:1656-1669
Methylmercury (MeHg) and perfluorooctanesulfonate (PFOS) are major contaminants of human blood that are both common in dietary fish, thereby raising questions about their combined impact on human development. Here, pregnant Sprague-Dawley rats ingest
Autor:
Francis Johnson, Jingshu Guo, Peter W. Villalta, Christopher J. Weight, Radha Bonala, Robert J. Turesky, Thomas A. Rosenquist
Publikováno v:
Chemical Research in Toxicology. 31:1382-1397
Epidemiological studies have linked aromatic amines (AAs) from tobacco smoke and some occupational exposures with bladder cancer risk. Several epidemiological studies have also reported a plausible role for structurally related heterocyclic aromatic
Autor:
Sharin E. Roth, Sean Hammond, Merrie Mosedale, Kanoot Jaruthamsophon, Dean J. Naisbitt, Andrew Gibson
Publikováno v:
Chemical Research in Toxicology
Tolvaptan is an effective drug for the treatment of autosomal dominant polycystic kidney disease, but its use is associated with a significant risk of liver injury in a small number of patients. Herein we describe the presence of tolvaptan- and tolva
Autor:
Sheena A Young, Benedict R. Capacio
Publikováno v:
Chemical research in toxicology. 33(7)
Exposures to sulfur mustard (HD; bis(2-chloroethyll) sulfide) are well-known to result in the formation of adducts with free aspartate and glutamate residues of plasma proteins (Lawrence, R. J., Smith, J. R., and Capacio, B. R. 2008 32, (1), 31-36).
Autor:
Rebekah E. Wharton, Geovannie Ojeda-Torres, Nicole L. Abbott, Rudolph C. Johnson, Craig Seymour, Melanie C. Feyereisen, Kasey L. Hill, Donna Hill, Brady R. Cunningham, Johnsie R. Lang, Elizabeth I. Hamelin
Publikováno v:
Chemical Research in Toxicology. 31:898-903
Microcystins are toxins produced by many cyanobacteria species, which are often released into waterways during blue-green algal blooms in freshwater and marine habitats. The consumption of microcystin-contaminated water is a public health concern as
Publikováno v:
Chemical Research in Toxicology. 30:2074-2083
Alkylating agents contained in cigarettes smoke might be related to cancer development. Post-translational protein methylation and ethylation may cause alteration of protein functions. Human hemoglobin (Hb) has been a target for molecular dosimetry b