Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Guo-Bo Li, Shengyong Yang, Michael A. McDonough, Jürgen Brem, James Spencer, Martine I. Abboud, Juan-Carlos Jiménez-Castellanos, Christopher T. Lohans, Christopher J. Schofield, Ian J. Clifton, Matthew B. Avison, Robert K. Lesniak
Publikováno v:
Chemical communications (Cambridge, England). 53(43)
Crystallographic analyses of the VIM-5 metallo-β-lactamase (MBL) with isoquinoline inhibitors reveal non zinc ion binding modes. Comparison with other MBL-inhibitor structures directed addition of a zinc-binding thiol enabling identification of pote
Autor:
Christopher J. Schofield, Armin Thalhammer, Timothy D. W. Claridge, Grazyna Kochan, Anna M. Rydzik, Ivanhoe K. H. Leung
Publikováno v:
Chemical communications (Cambridge, England). 50(10)
A convenient method for the synthesis of fluoromethylated carnitine biosynthesis intermediates, i.e. fluorinated derivatives of γ-butyrobetaine and trimethyllysine, is described. The fluoromethylated probes were useful in both in vitro and cell base
Autor:
Ineke P. Stolze, Neil J. Oldham, Benoît M. R. Liénard, Ana Conejo-García, Peter J. Ratcliffe, Christoph Loenarz, Christopher J. Schofield
Publikováno v:
Chemical communications (Cambridge, England). (47)
Known and potential aspirin metabolites were evaluated as inhibitors of oxygen-sensing hypoxia-inducible transcription factor (HIF) hydroxylases; some of the metabolites were found to stabilise HIF-alpha in cells.