Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Tohru Sugawara"'
Publikováno v:
Chemical and Pharmaceutical Bulletin. 49:1138-1146
An improved general method for automated synthesis of tripeptides was developed, in which methanesulfonic acid (MSA) was used in place of trifluoroacetic acid (TFA), thus making it possible to avoid, 1) corrosion of the apparatus by strong acid vapor
Publikováno v:
Chemical and Pharmaceutical Bulletin. 49:1147-1154
An in-house developed automated synthesis suite was used to prepare a library of 72 tetrapeptide derivatives, the starting materials for pharmaceutically attractive pentapeptides, employing a convergent strategy. An initial set of 18 dipeptides were
Publikováno v:
Chemical and Pharmaceutical Bulletin. 48:784-792
TAK-218 has a 2,3-dihydrobenzofuran-5-amine (coumaran) structure which resembles alpha-tocopherol, and is a promising candidate as an agent for central nervous system (CNS) trauma and ischemia. The radical scavenging activity of TAK-218 was studied u
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:1511-1515
For the purpose of improving the anti-asthmatic activity of 3-(imidazo[1,2-b]pyridazin-6-yl)thiopropanesulfonamide (I), the computer-assisted automated synthesis apparatus developed at Takeda was used to modify the sulfonamide moiety of I. Several ki
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:1272-1280
An automated synthesis system, which is suitable for repetitive syntheses using similar reaction procedures, was used to synthesize systematically a library of all possible dipeptides (25) and tripeptides (125) from 5 protected amino acids. The appar
Publikováno v:
Chemical and Pharmaceutical Bulletin. 28:2116-2128
3-(5-Substituted-1, 3, 4-thiadiazol-2-yl) ceph-3-em derivatives were prepared by oxidative ring closure with 2, 3-dichloro-5, 6-dicyanobenzoquinone directly or after acetylation of 3-thiocarbonylhydrazones, which were obtained from the reaction of 3-
Publikováno v:
Chemical and Pharmaceutical Bulletin. 22:823-831
Besides sennoside A, sennosides B, C, E and F were isolated from rhubarbs. Sennosides E and F are new compounds and have comparable purgative activity to other sennosides. Sennosides E and F are stereoisomer mutually, and they are oxalates of sennosi
Autor:
Yasuhiko Kawano, Tohru Sugawara, Hirotomo Masuya, Noriyoshi Noguchi, Taisuke Matsuo, Michihiko Ochiai
Publikováno v:
Chemical and Pharmaceutical Bulletin. 31:2200-2208
As a key intermediate for the synthesis of sulfazecin derivatives, 3-amino-3-methoxy-2-azetidinone (24 or 26) was synthesized from penicillins, and various new compounds, including sulfazecin, were synthesized by acylation and sulfonation of 24 or 26
Publikováno v:
Chemical and Pharmaceutical Bulletin. 27:3095-3100
Starting from cephalosporin thiolactones (1), a sequence of reactions (bromination, hydrolysis, oxidation and opening of the dioxo thiophene ring) yielded 3-carboxyceph-3-ems (10). Several reactions of thiolactone derivatives are also described.
Publikováno v:
Chemical and Pharmaceutical Bulletin. 26:3080-3100
Several new β-aminopyrroles, 3-aminoindoles, pyrido [3, 4-b] indoles, and pyrrolo-[3, 2-b] pyridines have been synthesized by a sequence of reactions involving intramolecular addition of an enamine to a cyano group. Enamine (1), prepared from tert-b