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Publikováno v:
Chemical and Pharmaceutical Bulletin. 58:1187-1194
P-Glycoprotein accounts for multidrug resistance in chemotherapy patients and contributes to reduced oral bioavailability and distribution of drugs in the brain. The aim of this study was to establish the qualitative and quantitative structure-activi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 58:168-171
We designed 1-alkyloxygenipins with the aim of improving the stability of genipins based on the structural and electronic properties of genipins, and prepared 1-alkyloxygenipins and examined their neuritogenic activities in PC12h cells. All genipin-d
Autor:
Taketo Yamaji, Tominari Choshi, Satoshi Hibino, Hideo Nemoto, Masashi Yamada, Tsutomu Oikawa, Hiroshi Tsuboi, Yoshitatsu Ichihara, Hiroto Suzuki, Yoshio Sato, Natsuko Murata, Junko Nobuhiro, Shiho Fujimori, Masayuki Uchida
Publikováno v:
Chemical and Pharmaceutical Bulletin. 54:1567-1570
We synthesized 9alpha-fluoromedroxyprogesterone acetate (FMPA) in order to test whether it is a more potent anti-angiogenic agent than medroxyprogesterone acetate (MPA), which has been widely used as a therapeutic agent for breast and endometrium can
Autor:
Sabine Witt, Wolf-Dieter Jülich, Susanne Hessel, Elke Hammer, Timo H. J. Niedermeyer, Michael Lalk, Simone Seefeldt, Manuela Gesell, Frieder Schauer, Annett Mikolasch, Ulrike Lindequist
Publikováno v:
Chemical and Pharmaceutical Bulletin. 54:632-638
Eight novel penicillins were synthesized by heteromolecular reaction of ampicillin or amoxicillin with 2,5-dihydroxybenzoic acid derivatives using a laccase from Trametes spec. All products inhibited the growth of several gram positive bacterial stra
Autor:
Sarfraz Ahmad Nawaz, Atta-ur-Rahman, Syed Adnan Ali Shah, Muhammad Iqbal Choudhary, Iffat Batool
Publikováno v:
Chemical and Pharmaceutical Bulletin. 53:1455-1459
Pregnenolone and pregnenolone acetate were incubated with the fungi Cunninghamella elegans, Rhizopus stolonifer and Gibberella fujikuroi. Incubation of with C. elegans yielded metabolites, 3beta,7beta,11alpha-trihydroxypreg-5-en-20-one, 3beta,6alpha,
Publikováno v:
Chemical and Pharmaceutical Bulletin. 52:494-497
New dolabellane-type diterpene alkaloids, nigellamines A(3), A(4), A(5), and C, were isolated from the methanolic extract of an Egyptian medicinal food, black cumin (the seeds of Nigella sativa). Their absolute configurations were determined on the b
Autor:
Tsuyoshi Maekawa, Yu Momose, Masatoshi Hazama, Katsuhito Murase, Hiroyuki Tawada, Yasuo Sugiyama, Nozomu Sakai
Publikováno v:
Chemical and Pharmaceutical Bulletin. 51:565-573
A novel series of 5-(omega-aryloxyalkyl)oxazole derivatives was prepared and their effects on brain-derived neurotrophic factor (BDNF) production were evaluated in human neuroblastoma (SK-N-SH) cells. Syntheses were performed by construction of an ox
Autor:
Eugene Bratoeff, Elena Ramírez, Eugenio Flores, Ivonne Heuze, Norma Valencia, Mauricio Sánchez, Marisa Cabeza
Publikováno v:
Chemical and Pharmaceutical Bulletin. 51:1132-1136
The in vitro inhibitory activity of five new progesterone derivatives: 17alpha-hydroxy-16beta-methylpregna-1,4,6-triene-3,20-dione 1; 16beta-methyl-17alpha-toluoyloxypregna-1,4,6-triene-3,20-dione 2; 17alpha-hydroxy-6-methylenepregn-4-ene-3,20-dione
Publikováno v:
Chemical and Pharmaceutical Bulletin. 50:337-340
Following the finding of in vitro insulinominetic activities of new prepared Zn(II) complexes with amide ligands (2-picolinamide (pa-a) and 6-methyl-2-picolinmethylamide (6mpa-ma)) in isolated rat adipocytes treated with epinephrine in terms of inhib
Publikováno v:
Chemical and Pharmaceutical Bulletin. 50:272-275
We report the synthesis and radioligand binding analysis of a series of naphthalenic melatonin receptor ligands, N-[2-(7-alkoxy-2-methoxy-1-naphthyl)ethyl]propionamide. This series of ligands exhibits subpicomolar binding affinity to both MT1 and MT2