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Publikováno v:
Cellular signalling. 91
Background The hyperglycemic microenvironment induced by diabetes mellitus aggravates the inflammatory response, in which the inositol-requiring enzyme-1α (IRE1α) signal transduction pathway of the unfolded protein response (UPR) participates. This
Publikováno v:
Cellular signalling. 85
Signaling by the bioactive sphingolipid, sphingosine 1–phosphate (S1P), and its precursors are emerging areas in pregnancy research. S1P and ceramide levels increase towards end of gestation, suggesting a physiological role in parturition. However,
Autor:
Karin G. Stenkula, Olga Göransson, Franziska Kopietz, Jurga Laurencikiene, Johanna Säll, Björn Hansson, Mikael Ekelund, Eva Degerman, Wilhelm Linder, Annie M. L. Pettersson, Florentina Negoita
Publikováno v:
Cellular Signalling. 55:73-80
Aims/hypothesis Salt-inducible kinase 2 (SIK2) is downregulated in adipose tissue from obese or insulin-resistant individuals and inhibition of SIK isoforms results in reduced glucose uptake and insulin signalling in adipocytes. However, the regulati
Publikováno v:
Cellular signalling. 82
Insulin is the main anabolic hormone secreted by β-cells of the pancreas stimulating the assimilation and storage of glucose in muscle and fat cells. It modulates the postprandial balance of carbohydrates, lipids and proteins via enhancing lipogenes
Publikováno v:
Cellular signalling. 80
Colorectal cancer (CRC) is a noticeable reason of cancer-associated deaths with a high incidence and mortality rate. Countless effort have been put into the improving clinical management of CRC patients including more effective tools and a wide varie
Autor:
Neema S. Patel, Reagan Farmer, Angelo Sarmiento, Michy P. Kelly, Steven D. Burbano, Abigail J. Smith
Publikováno v:
Cell Signal
Many studies implicate altered cyclic nucleotide signaling in the pathophysiology of major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SCZ). As such, we explored how phosphodiesterases 2A (PDE2A) and 10A (PDE10A)-enzymes tha
Autor:
Rajkumar Savai, Friedrich Grimminger, Martina Barbara Schaefer, Annika Karger, Poonam Sarode, Siavash Mansouri, Werner Seeger
Publikováno v:
Cellular signalling. 65
Lung cancer is the leading cause of cancer death for both men and women and accounts for almost 18.4% of all deaths due to cancer worldwide, with the global incidence increasing by approximately 0.5% per year. Lung cancer is regarded as a devastating
Publikováno v:
Cellular signalling. 67
Excessive circulating free fatty acids (FFA) cause insulin resistance in peripheral tissues by inhibiting the proximal insulin signaling pathway. White adipose tissue (WAT) is a primary source of FFA generation and release through triglyceride (TG) h
Autor:
Courtney Cleland, Mini P. Sajan, Fabienne Foufelle, Joshua Sajan, Robert V. Farese, Mackenzie C. Lee
Publikováno v:
Cellular Signalling. 43:62-70
Type 2 diabetes is characterized by insulin resistance, hyperinsulinemia and hepatic overproduction of glucose and lipids. Insulin increases lipogenic enzyme expression by activating Akt and aPKC which activate SREBP-1c; this pathway is hyperactivate
Autor:
Michy P. Kelly
Publikováno v:
Cellular Signalling. 42:281-291
Deficits in brain function that are associated with aging and age-related diseases benefit very little from currently available therapies, suggesting a better understanding of the underlying molecular mechanisms is needed to develop improved drugs. H