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Publikováno v:
Cellular signalling. 13(6)
Ca 2+ mobilisation from internal stores and from the extracellular medium is one of the primary events involved in lymphocyte activation and proliferation. Regulation of these processes by adenosine 3′,5′-cyclic monophosphate (cAMP) and cAMP-depe
Publikováno v:
Cellular signalling. 13(5)
Tumor necrosis factor-alpha (TNF-alpha) is involved in insulin resistance. Since the fact that peroxisome proliferator-activated receptor gamma (PPARgamma) ligands inhibit the induction of TNF-alpha by phorbol ester, but not by lipopolysaccharide (LP
Autor:
Sanae Shimura
Publikováno v:
Cellular signalling. 12(5)
Bronchial glands, which consist of mucous and serous cells, are abundant in human airways, playing a major role in the airway secretion. Cl(-) secretion is accompanied by water transport to the lumen in the acinar cells of bronchial glands. Agonists
Autor:
Kazuo Kajita, Masayoshi Ishizawa, Yoshinori Kanoh, Hiroya Sakuma, Tatsuo Ishizuka, Atsushi Miura, Keigo Yasuda, Mika Kimura, Hiroyuki Morita, Takeshi Suzuki
Publikováno v:
Cellular signalling. 12(4)
It has been reported that pertussis toxin (PTX) suppresses the function of trimeric guanine nucleotide binding protein (G-protein). We examined the effect of PTX on insulin-induced glucose uptake, diacylglycerol (DG)-protein kinase C (PKC) signalling
Publikováno v:
Cellular signalling. 11(10)
Prolonged exposure of cells to an agonist of a G-protein-coupled receptor usually results in an attenuation of the cellular response. To elucidate the cellular mechanisms of sensitization or desensitization in an insulin secretory cell system (INS-1
Autor:
Thérèse-Marie Mignot, Céline Méhats, G. Grangé, Paulette Duc-Goiran, Marie-Josèphe Leroy, Françoise Ferré, Emmanuelle Dallot, Brigitte Robert, G. Tanguy
Publikováno v:
Cellular signalling. 11(1)
In light of the important role of the second messengers cAMP and cGMP in the mechanism of relaxation in the human myometrium, specific regulation of the phosphodiesterase (PDE) enzymatic system responsible for cyclic nucleotide inactivation is essent
Publikováno v:
Cellular signalling. 11(2)
Interferon-gamma (IFN-gamma) has multiple effects on Ca2+ signalling in polymorphonuclear neutrophils (PMNs), including evoked cytosolic Ca2+ transients, increased capacitative calcium influx and increased sequestration of Ca2+ in intracellular store
Publikováno v:
Cellular signalling. 9(6)
To investigate whether G protein-coupled receptor kinases (GRKs) are involved in the regulation of the PTH/PTHrPR, we have established mutant SaOS-2 cells which stably overexpress (10-20-fold) a dominant negative form of the beta-adrenergic receptor
Publikováno v:
Cellular signalling. 9(1)
Metabolism of arachidonic acid has been found to modulate cell growth and differentiation. Since differentiation of premonocytic U937 cells is paralleled by increased expression of cyclooxygenase and prostanoid synthesis, we assessed the role of cycl
Autor:
Maria Luisa Colamussi, Maria Cristina Pareschi, Susanna Spisani, Serena Traniello, Carla Biondi, Maria Enrica Ferretti, Ines Torrini, Mario Paglialunga Paradisi, Marco Buzzi, Giampiero Pagani Zecchini
Publikováno v:
Cellular signalling. 8(4)
The increase in human neutrophil cyclic adenosine monophosphate (cAMP) levels evoked by formylated peptides is significantly reduced in the presence of MDL 12330A, SQ 22536, GDPβS and clonidine, which inhibit the adenylyl cyclase system by acting at