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Publikováno v:
Cellular signalling. 91
Background The hyperglycemic microenvironment induced by diabetes mellitus aggravates the inflammatory response, in which the inositol-requiring enzyme-1α (IRE1α) signal transduction pathway of the unfolded protein response (UPR) participates. This
Publikováno v:
Cellular signalling. 85
Signaling by the bioactive sphingolipid, sphingosine 1–phosphate (S1P), and its precursors are emerging areas in pregnancy research. S1P and ceramide levels increase towards end of gestation, suggesting a physiological role in parturition. However,
Publikováno v:
Cellular signalling. 82
Insulin is the main anabolic hormone secreted by β-cells of the pancreas stimulating the assimilation and storage of glucose in muscle and fat cells. It modulates the postprandial balance of carbohydrates, lipids and proteins via enhancing lipogenes
Publikováno v:
Cellular signalling. 80
Colorectal cancer (CRC) is a noticeable reason of cancer-associated deaths with a high incidence and mortality rate. Countless effort have been put into the improving clinical management of CRC patients including more effective tools and a wide varie
Autor:
Rajkumar Savai, Friedrich Grimminger, Martina Barbara Schaefer, Annika Karger, Poonam Sarode, Siavash Mansouri, Werner Seeger
Publikováno v:
Cellular signalling. 65
Lung cancer is the leading cause of cancer death for both men and women and accounts for almost 18.4% of all deaths due to cancer worldwide, with the global incidence increasing by approximately 0.5% per year. Lung cancer is regarded as a devastating
Publikováno v:
Cellular signalling. 67
Excessive circulating free fatty acids (FFA) cause insulin resistance in peripheral tissues by inhibiting the proximal insulin signaling pathway. White adipose tissue (WAT) is a primary source of FFA generation and release through triglyceride (TG) h
Autor:
Courtney Cleland, Mini P. Sajan, Fabienne Foufelle, Joshua Sajan, Robert V. Farese, Mackenzie C. Lee
Publikováno v:
Cellular Signalling. 43:62-70
Type 2 diabetes is characterized by insulin resistance, hyperinsulinemia and hepatic overproduction of glucose and lipids. Insulin increases lipogenic enzyme expression by activating Akt and aPKC which activate SREBP-1c; this pathway is hyperactivate
Autor:
Yongxia Chen, Wuguo Deng, Ji Wang, Miao Chen, Hanchu Xiong, Yunlu Jia, Wenhe Zhao, Wenxian Hu, Jichun Zhou, Linbo Wang, Xiaogang Ying, Xiao Luo
Publikováno v:
Cellular Signalling. 42:165-175
Tamoxifen resistance represents a daunting challenge to the successful treatment for breast cancer. Krüppel-like factor 4 has critical roles in the development and progression of breast cancer, but its expression, function and regulation in the effi
Autor:
Peter Storz, Alicia K. Fleming
Publikováno v:
Cellular Signalling. 40:1-9
Protein Kinase C isoforms have been implicated in regulating multiple processes within the healthy pancreas. Moreover, their dysregulation contributes to all aspects of pancreatic disease. In this review, with a focus on acinar, ductal, and islet cel
Autor:
Karim Nagi, Abdella M. Habib
Publikováno v:
Cellular Signalling. 83:109976
Obesity is a global burden and a chronic ailment with damaging overall health effects. Ghrelin, an octanoylated 28 amino acid peptide hormone, is secreted from the oxyntic mucosa of the stomach. Ghrelin acts on regions of the hypothalamus to regulate