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Autor:
Michy P. Kelly
Publikováno v:
Cellular Signalling. 42:281-291
Deficits in brain function that are associated with aging and age-related diseases benefit very little from currently available therapies, suggesting a better understanding of the underlying molecular mechanisms is needed to develop improved drugs. H
Autor:
Surleen Kaur, G. Anjali, Ruchi Lakra, Jyoti Taneja, Alka Kriplani, Rita Singh, Tulsidas G. Shrivastav, Anjali Nagendra, M. Gouri Devi, Neena Malhotra, Gaganjot Singh Kalsey
Publikováno v:
Cellular Signalling. 27:2452-2466
Follicle stimulating hormone (FSH) plays a central role in growth and differentiation of ovarian follicles. A plethora of information exists on molecular aspects of FSH responses but little is known about the mechanisms involved in its cross-talk wit
Autor:
Rumin Zhang, Chuanxin Liu, Yunlu Jiang, Jing Chen, Xin Cai, Xiaoyu Chen, Haiqing Liu, Chunmei Wang, Bo Bai
Publikováno v:
Cellular Signalling. 27:1426-1438
Orexin and dynorphin are co-expressed in the same synaptic vesicles of hypothalamic neurons and play opposing roles in cocaine self-administration, brain stimulation reward, and impulsivity in ventral tegmental area (VTA), where dopamine neurons expr
Autor:
Keven R. Johnson, Andrei V. Karginov, Randal A. Skidgel, John P. O'Bryan, Brian T. Burmeister, Graeme K. Carnegie, Li Wang, George S. Baillie
Publikováno v:
Cellular Signalling. 27:908-922
Hypertrophy increases the risk of heart failure and arrhythmia. Prevention or reversal of the maladaptive hypertrophic phenotype has thus been proposed to treat heart failure. Chronic β-adrenergic receptor (β-AR) stimulation induces cardiomyocyte h
Autor:
Martin F. Fromm, Wolfgang Schuh, Hartmut Glaeser, Kathrin Mandery, Krystyna Bujok, Tilman T. Rau, Ingrid Schmidt
Publikováno v:
Cellular Signalling. 27:663-672
Prostaglandins such as prostaglandin E2 (PGE2) play a pivotal role in physiological and pathophysiological pathways in gastric mucosa. Little is known about the interrelation of the prostaglandin E (EP) receptors with the prostaglandin transporter OA
Publikováno v:
Cellular Signalling
Platelets store and secrete the chemokine stromal cell-derived factor (SDF)-1α upon platelet activation, but the ability of platelet-derived SDF-1α to signal in an autocrine/paracrine manner mediating functional platelet responses relevant to throm
Publikováno v:
Cellular Signalling. 24:1863-1871
Salt-inducible kinase (SIK) 3 is a virtually unstudied, ubiquitously expressed serine/threonine kinase, belonging to the AMP-activated protein kinase (AMPK)-related family of kinases, all of which are regulated by LKB1 phosphorylation of a threonine
Publikováno v:
Cellular Signalling. 21:760-766
AMP-activated protein kinase (AMPK) is an important regulator of cellular energy status. In adipocytes, stimuli that increase intracellular cyclic AMP (cAMP) have also been shown to increase the activity of AMPK. The precise molecular mechanisms resp
Publikováno v:
Cellular Signalling
In humans, thromboxane (TX) A2 signals through the TPalpha and TPbeta isoforms of the TXA2 receptor that exhibit common and distinct roles. For example, Gq/phospholipase (PL)Cbeta signaling by TPalpha is directly inhibited by the vasodilators prostac
Autor:
Jeffrey J. Martino, Jin Namkoong, Karine A. Cohen-Solal, Suzie Chen, Yarí E. Marín, Seung-Shick Shin, Masahiro Oka
Publikováno v:
Cellular Signalling. 18:1279-1286
Metabotropic glutamate receptor 1 (Grm1, formerly mGluR1) is a G protein coupled receptor (GPCR) normally expressed and functional in the central nervous system. Studies of our transgenic mouse melanoma model (TG-3) revealed that ectopic expression o